Screening and the prevention of gynecologic cancer: Endometrial cancer Journal Article
| Authors: | Sonoda, Y.; Barakat, R. R. |
| Article Title: | Screening and the prevention of gynecologic cancer: Endometrial cancer |
| Abstract: | Over the years, endometrial cancer has remained the most common gynecologic malignancy in the United States. Two categories of endometrial cancer exist: type I and type II. Type I cancers constitute the majority of cases of endometrial cancer, and the risk factors for this type have been studied in greatest detail. These cancers are driven by estrogen, and many of the risk factors are directly or indirectly linked to a state of excessive estrogen. Protective factors seem to be related to conditions that may result in decreased estrogen exposure. Cure rates for endometrial cancer remain high, mainly because of the early stage at which the majority of cases present. Warning signs of abnormal vaginal bleeding or discharge allow detection of these cancers in their early stages. Screening for these cancers is not effective and often leads to additional unnecessary tests; thus, it is not currently recommended in the general population. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | treatment outcome; gene mutation; clinical feature; review; placebo; cancer risk; hypertension; united states; cancer staging; endometrial cancer; hysterectomy; endometrial neoplasms; endometrium cancer; salpingooophorectomy; sensitivity and specificity; caloric intake; colorectal cancer; disease association; estrogen; risk factors; obesity; cancer screening; mass screening; prediction; risk factor; menarche; color ultrasound flowmetry; early diagnosis; screening; diabetes mellitus; tamoxifen; physical activity; antineoplastic agents, hormonal; cancer classification; menopause; genetic predisposition; gynecologic cancer; protein mlh1; protein msh2; protein msh6; oral contraceptive agent; mismatch repair protein pms2; hysteroscopy; endometrium biopsy; hormone substitution; life style; unnecessary procedure; conjugated estrogen; gestagen; prevention; vagina bleeding; fat intake; neoplastic syndromes, hereditary; transvaginal echography; parity; reproductive history; vagina discharge; conjugated estrogen plus medroxyprogesterone acetate |
| Journal Title: | Best Practice and Research: Clinical Obstetrics and Gynaecology |
| Volume: | 20 |
| Issue: | 2 |
| ISSN: | 1521-6934 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-04-01 |
| Start Page: | 363 |
| End Page: | 377 |
| Language: | English |
| DOI: | 10.1016/j.bpobgyn.2005.10.015 |
| PUBMED: | 16364689 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 4 June 2012" - "CODEN: BPRCF" - "Source: Scopus" |
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