The current clinical approach to newly diagnosed uterine cancer Review
| Authors: | Filippova, O. T.; Leitao, M. M. |
| Review Title: | The current clinical approach to newly diagnosed uterine cancer |
| Abstract: | Introduction: Uterine cancer is the most common gynecologic malignancy, although fortunately, 75% of women present with early-stage disease. A major area of controversy regarding the management of the disease concerns postoperative therapy for both women with early- and advanced-stage endometrial carcinoma. Here, we review landmark evidence that can help guide clinical decision-making in the treatment of women diagnosed with endometrial cancer. Areas covered: In this review, we present the latest data driving decisions for both surgical management and postoperative therapy for women with endometrial carcinoma. Areas discussed include surgical staging, with a specific discussion on the role of sentinel lymph node mapping, and postoperative therapy, ranging from the data supporting observation for women with early-stage, low-risk disease to combination therapy for women with advanced disease. Less common histologies, such as serous and clear cell carcinoma, as well as carcinosarcoma, will also be covered. Furthermore, a section of the paper is dedicated to the current state of fertility-sparing surgery. Expert opinion: We suggest several approaches for deciding on adjuvant therapy, based on stage and histology, after comprehensive surgical staging. The role that endometrial cancer molecular subtypes will play on postoperative therapy remains to be fully investigated. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | review; bevacizumab; cisplatin; doxorubicin; cancer combination chemotherapy; cancer risk; drug safety; paclitaxel; adjuvant therapy; cancer adjuvant therapy; postoperative care; cancer staging; endometrial cancer; endometrium carcinoma; hysterectomy; lymph node dissection; sentinel lymph node mapping; endometrium cancer; laparotomy; sentinel lymph node; medical decision making; carboplatin; neuropathy; histology; ifosfamide; docetaxel; temsirolimus; cancer hormone therapy; drug fatality; conservative treatment; tamoxifen; intermethod comparison; external beam radiotherapy; clear cell carcinoma; mesna; uterus cancer; cytopenia; female fertility; ascites fluid cytology; megestrol acetate; ixabepilone; surgical staging; carcinosarcoma; fertility preservation; ovarian preservation; clear cell; endometrioid; serous; fertility-sparing treatment; human |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 20 |
| Issue: | 7 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2020-07-01 |
| Start Page: | 581 |
| End Page: | 590 |
| Language: | English |
| DOI: | 10.1080/14737140.2020.1782750 |
| PUBMED: | 32531179 |
| PROVIDER: | scopus |
| PMCID: | PMC7416456 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 September 2020 -- Source: Scopus |
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