Update on hereditary breast cancer Journal Article
| Authors: | Smith, K. L.; Robson, M. E. |
| Article Title: | Update on hereditary breast cancer |
| Abstract: | Women with BRCA1 or BRCA2 mutations are at substantial risk for breast and ovarian cancer. This review describes recent developments in the approach to hereditary breast cancer. Risk-reducing surgeries remain the most effective means of preventing breast cancer in mutation carriers. For women with breast tissue at risk, magnetic resonance imaging is rapidly becoming incorporated into screening programs. For affected women, management does not currently differ from that of women with sporadic breast cancer, although women may choose to undergo bilateral mastectomy. Preclinical data suggest that BRCA mutation associated breast cancers may benefit from specific targeted therapeutic approaches. Copyright © 2006 by Current Science Inc. |
| Keywords: | treatment outcome; gene mutation; review; cancer recurrence; cisplatin; cancer combination chemotherapy; cancer risk; united states; drug targeting; cancer staging; nuclear magnetic resonance imaging; follow up; sensitivity and specificity; cancer prevention; chemoprophylaxis; consensus; breast cancer; gene expression; mastectomy; protein targeting; ovariectomy; prevalence; epidermal growth factor receptor 2; aromatase inhibitor; cancer screening; smoking; tumor biopsy; enzyme activity; breast neoplasms; brca1 protein; brca2 protein; risk factor; cancer mortality; risk assessment; carcinogenesis; cancer hormone therapy; mammography; early diagnosis; genes, brca1; genes, brca2; tamoxifen; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; checkpoint kinase 2; familial cancer; coffee; antineoplastic agents, hormonal; taxane derivative; estrogen receptor; mitomycin; risk reduction; drug sensitivity; oral contraceptive agent; primary prevention; germ-line mutation; antiestrogen; heterozygote detection; parity; selective estrogen receptor modulator; breast feeding |
| Journal Title: | Current Oncology Reports |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2006-01-01 |
| Start Page: | 14 |
| End Page: | 21 |
| Language: | English |
| PUBMED: | 16464398 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 4 June 2012" - "CODEN: CORUA" - "Source: Scopus" |
