Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours Journal Article
| Authors: | Ruschenburg, I.; Vollheim, B.; Stachura, J.; Cordon-Cardo, C.; Korabiowska, M. |
| Article Title: | Analysis of DNA mismatch repair gene expression and mutations in thyroid tumours |
| Abstract: | Alterations of DNA mismatch repair genes, primarily demonstrated in hereditary nonpolyposis colorectal carcinomas, were reported to be of relevance for the progression of several sporadic tumours. In this study, the expression and mutations of MLH1, MSH2, PMS1 and PMS2 in a panel of thyroid tumours, including nodular hyperplasia, follicular adenomas and carcinomas, were investigated. The expressions of MLH1, MSH2 and PMS1 were generally higher in malignant tumours than in benign lesions (p<0.01). This observation can find potential diagnostic application in the differentiation of follicular adenomas from follicullar carcinomas of the thyroid. No point mutations in the DNA mismatch repair genes MSH2 (exon 12, 13) and MLH1 (exon 15, 16) were found. |
| Keywords: | adolescent; adult; protein expression; aged; middle aged; unclassified drug; major clinical study; mutation; dna-binding proteins; dna repair; gene expression; carcinoma, papillary; neoplasm proteins; nuclear proteins; adenoma; molecular sequence data; mismatch repair; dna mismatch repair; hyperplasia; carrier proteins; dna repair enzymes; base sequence; neoplasm invasiveness; thyroid cancer; thyroid neoplasms; thyroid gland; point mutation; protein mlh1; protein msh2; adenosine triphosphatases; muts homolog 2 protein; thyroid follicle; thyroid tumor; adenocarcinoma, follicular; mismatch repair protein pms2; follicular carcinoma; msh2; nucleic acid binding protein; base pair mismatch; nodular hyperplasia; mlh1; pms2; pms1; mismatch repair protein pms1 |
| Journal Title: | Anticancer Research |
| Volume: | 26 |
| Issue: | 3A |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2006-05-01 |
| Start Page: | 2107 |
| End Page: | 2112 |
| Language: | English |
| PUBMED: | 16827152 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: ANTRD" - "Source: Scopus" |
