Exonic deletions of mismatch repair genes MLH1 and MSH2 correlate with prognosis and protein expression levels in malignant melanomas Journal Article
| Authors: | Korabiowska, M.; Brinck, U.; Stachura, J.; Jawien, J.; Hasse, F. M.; Cordon-Cardo, C.; Fischer, G. |
| Article Title: | Exonic deletions of mismatch repair genes MLH1 and MSH2 correlate with prognosis and protein expression levels in malignant melanomas |
| Abstract: | The mutations of MLH1 and MSH2 have been reported to be responsible for malignant transformation and tumour progression in several sporadic tumours. Eighty-six primary malignant melanomas with known follow-up were investigated. Point mutations of DNA mismatch repair MLH1 and MSH2 in malignant melanomas were not found. Exon 12 (MSH2) was not present in 26 out of the 86 melanomas and exon 13 (MSH2) was lost in 25 of the tumours. The loss of exon 15 (MLH1) was observed in 22 out of the 86 tumours and the loss of exon 16 (MLH1) in 24 melanomas. The loss of exons correlated strongly with the loss of MLH1 and MSH2 protein expression. In multivariate analysis, including all 4 exons and expressions of MLH1 and MSH2, prognostic significance was found only for loss of exon 12 (MSH2) and loss of exon 15 (MLH1). |
| Keywords: | controlled study; human tissue; protein expression; survival rate; gene mutation; major clinical study; exon; gene deletion; mutation; exons; follow up; dna repair; melanoma; proportional hazards models; nuclear proteins; dna; mismatch repair; carrier proteins; chromosome translocation; multivariate analysis; malignant melanoma; kaplan meier method; tumor growth; point mutation; uvea melanoma; malignant transformation; protein mlh1; protein msh2; muts homolog 2 protein; msh2; base pair mismatch; mlh1 |
| Journal Title: | Anticancer Research |
| Volume: | 26 |
| Issue: | 2A |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2006-03-01 |
| Start Page: | 1231 |
| End Page: | 1235 |
| Language: | English |
| PUBMED: | 16619529 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: ANTRD" - "Source: Scopus" |
