Structural biology of RNA silencing and its functional implications Conference Paper
| Authors: | Patel, D. J.; Ma, J. B.; Yuan, Y. R.; Ye, K.; Pei, Y.; Kuryavyi, V.; Malinina, L.; Meister, G.; Tuschl, T. |
| Title: | Structural biology of RNA silencing and its functional implications |
| Conference Title: | 71st Cold Spring Harbor Symposium on Quantitative Biology |
| Abstract: | We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5′-phosphate and 2-nucleotide 3′ overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release. © 2006 Cold Spring Harbor Laboratory Press. |
| Keywords: | genetics; review; metabolism; microrna; biological model; models, biological; small interfering rna; rna, small interfering; rna interference; biosynthesis; bacterial protein; chemistry; bacterial proteins; messenger rna; rna, messenger; models, molecular; protein structure, tertiary; chemical structure; micrornas; protein tertiary structure; ribonuclease iii; virus protein; viral proteins; initiation factor; peptide initiation factors |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 71 |
| Conference Dates: | 2006 May 31-Jun 5 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2006-01-01 |
| Start Page: | 81 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1101/sqb.2006.71.053 |
| PUBMED: | 17381284 |
| PROVIDER: | scopus |
| PMCID: | PMC4689314 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 4 June 2012" - "CODEN: CSHSA" - "Source: Scopus" |
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