The logic of TGFβ signaling Journal Article
| Authors: | Massague, J.; Gomis, R. R. |
| Article Title: | The logic of TGFβ signaling |
| Abstract: | The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis. © 2006 Federation of European Biochemical Societies. |
| Keywords: | signal transduction; review; cancer growth; nonhuman; protein analysis; animal; metabolism; animals; cell cycle; drug inhibition; metastasis; smad protein; transforming growth factor beta; transcription factor; cell fate; genetic transcription; transcription, genetic; protein serine threonine kinase; transcriptomics; cancer invasion; cancer inhibition; genome analysis; gene activation; cytokine; signal peptide; gene repression; cell cycle arrest; short survey; tumor suppressor; cyclin dependent kinase inhibitor; cyclin-dependent kinase; cytostasis; transcription factor foxo; tgfΒ; membrane receptor; receptor serine/threonine kinase; smad transcription factor; protein kinase (calcium,calmodulin) ii |
| Journal Title: | FEBS Letters |
| Volume: | 580 |
| Issue: | 12 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-05-22 |
| Start Page: | 2811 |
| End Page: | 2820 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2006.04.033 |
| PUBMED: | 16678165 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 303" - "Export Date: 4 June 2012" - "CODEN: FEBLA" - "Source: Scopus" |
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