Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex Journal Article
| Authors: | Hou, B. L.; Bradbury, M.; Peck, K. K.; Petrovich, N. M.; Gutin, P. H.; Holodny, A. I. |
| Article Title: | Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex |
| Abstract: | We utilized blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) and MR perfusion imaging methods to study the influence of brain tumor neovascularity on the BOLD fMRI activation volume in the primary motor cortex (PMC). The results from 57 brain tumor cases demonstrated that, for grade IV gliomas only, decreases in the BOLD fMRI activation volumes within the ipsilateral PMC, when compared with that observed in the contralateral PMC, correlated with increases in the relative regional cerebral blood volume (rCBV) in the PMC. In addition, relative increases in the activation volumes, corresponding to decreases in the rCBV, exhibited a linear dependence on the distance between the grade IV glioma and PMC. These findings lend support to the hypothesis that decreases in the fMRI activation volumes adjacent to a GBM may, in part, be due to the increased contribution of aberrant tumor neovascularity, with the resultant de-coupling of blood flow from neuronal activity. The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; major clinical study; neuroimaging; brain tumor; glioma; brain neoplasms; magnetic resonance imaging; cancer grading; statistics; oxygen; neurons; neovascularization, pathologic; correlation analysis; image enhancement; meningeal neoplasms; glioblastoma; glioblastoma multiforme; oligodendroglioma; meningioma; hemangiopericytoma; functional magnetic resonance imaging; motor cortex; image processing, computer-assisted; blood volume; astrocytoma; brain blood volume; blood oxygenation; magnetic resonance angiography; regional blood flow; blood oxygenation level dependent; prime motor cortex; relative regional cerebral blood volume |
| Journal Title: | NeuroImage |
| Volume: | 32 |
| Issue: | 2 |
| ISSN: | 1053-8119 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2006-08-15 |
| Start Page: | 489 |
| End Page: | 497 |
| Language: | English |
| DOI: | 10.1016/j.neuroimage.2006.04.188 |
| PUBMED: | 16806983 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 4 June 2012" - "CODEN: NEIME" - "Source: Scopus" |
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