The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumors Journal Article


Authors: Kim, M. J. J.; Holodny, A. I.; Hou, B. L.; Peck, K. K.; Moskowitz, C. S.; Bogomolny, D. L.; Gutin, P. H.
Article Title: The effect of prior surgery on blood oxygen level-dependent functional MR imaging in the preoperative assessment of brain tumors
Abstract: BACKGROUND AND PURPOSE: Blood oxygen level-dependent functional MR imaging (BOLD fMRI) is a clinically useful technique for preoperative mapping of eloquent cortices in patients with brain tumors. The purpose of this study was to determine the effect on BOLD fMRI accuracy of susceptibility artifacts caused by prior surgery by comparing volumes of activation in the primary motor cortex (PMC) of patients with and without prior brain surgery. METHODS: The volumes of fMRI activation of the PMC were measured for the tumor and nontumor sides in patients with (n = 13) and without (n = 30) prior neurosurgery. Statistical comparisons of the volumes were performed by using paired t tests and linear regression analysis. The location and degree of susceptibility artifact were subjectively assessed. RESULTS: No significant difference was found between the mean tumor and nontumor volumes of fMRI activations in patients without prior surgery (P = .51). In patients who had prior surgery, the volume of activation was significantly smaller on the side of the prior operation when compared with the contralateral side (P = .001). The volume of activation on the side of the tumor was also significantly smaller in the patients with prior surgery compared with those without prior surgery (P < .001). Nevertheless, the PMC was identified in all cases, and its location was confirmed intraoperatively. CONCLUSION: Prior surgery is associated with a decrease in the volume of fMRI activation in patients with prior surgery; however, by examining the T2 images, an astute radiologist can recognize this phenomenon, draw the appropriate conclusions, and correctly identify the PMC. © American Society of Neuroradiology.
Keywords: adult; clinical article; aged; aged, 80 and over; middle aged; preoperative care; nuclear magnetic resonance imaging; brain tumor; neurosurgery; brain neoplasms; magnetic resonance imaging; preoperative evaluation; linear models; oxygen; blood; medical record; artifact; functional magnetic resonance imaging; motor cortex; brain mapping; statistical model; artifacts; brain surgery; neurosurgical procedures; medical records; oxygen blood level
Journal Title: American Journal of Neuroradiology
Volume: 26
Issue: 8
ISSN: 0195-6108
Publisher: American Society of Neuroradiology  
Date Published: 2005-09-01
Start Page: 1980
End Page: 1985
Language: English
PUBMED: 16155146
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 21" - "Export Date: 24 October 2012" - "CODEN: AAJND" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Philip H Gutin
    163 Gutin
  2. Bob L Hou
    22 Hou
  3. Chaya S. Moskowitz
    251 Moskowitz
  4. Kyung Peck
    109 Peck
  5. Andrei Holodny
    196 Holodny