Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination Journal Article
| Authors: | De Piccoli, G.; Cortes-Ledesma, F.; Ira, G.; Torres-Rosell, J.; Uhle, S.; Farmer, S.; Hwang, J. Y.; Machin, F.; Ceschia, A.; McAleenan, A.; Cordon-Preciado, V.; Clemente-Blanco, A.; Vilella-Mitjana, F.; Ullal, P.; Jarmuz, A.; Leitao, B.; Bressan, D.; Dotiwala, F.; Papusha, A.; Zhao, X.; Myung, K.; Haber, J. E.; Aguilera, A.; Aragón, L. |
| Article Title: | Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination |
| Abstract: | DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events. |
| Keywords: | controlled study; nonhuman; dna replication; cell cycle proteins; dna damage; homologous recombination; cell survival; dna repair; sister chromatid; cell protein; dna strand breakage; dna; double stranded dna; saccharomyces cerevisiae; genomic instability; sister chromatid exchange; chromosome rearrangement; saccharomyces cerevisiae proteins; deoxyribonucleases, type ii site-specific |
| Journal Title: | Nature Cell Biology |
| Volume: | 8 |
| Issue: | 9 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-09-01 |
| Start Page: | 1032 |
| End Page: | 1034 |
| Language: | English |
| DOI: | 10.1038/ncb1466 |
| PUBMED: | 16892052 |
| PROVIDER: | scopus |
| PMCID: | PMC4493748 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 64" - "Export Date: 4 June 2012" - "CODEN: NCBIF" - "Source: Scopus" |
