Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness Journal Article


Authors: Yaligar, J.; Thakur, S. B.; Bokacheva, L.; Carlin, S.; Thaler, H. T.; Rizwan, A.; Lupu, M. E.; Wang, Y.; Matei, C. C.; Zakian, K. L.; Koutcher, J. A.
Article Title: Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness
Abstract: Longitudinal studies of lactate MRSI and dynamic contrast-enhanced MRI were performed at 4.7T in two prostate tumor models grown in rats, Dunning R3327-AT (AT) and Dunning R3327-H (H), to determine the potential of lactate and the perfusion/permeability parameter Ak ep as markers of tumor aggressiveness. Subcutaneous AT (n=12) and H (n=6) tumors were studied at different volumes between 100 and 2900mm 3 (Groups 1-5). Lactate concentration was determined using selective multiple quantum coherence MRSI with the phantom substitution method. Tumor enhancement after the administration of gadolinium diethylenetriaminepenta-acetic acid was analyzed using the Brix-Hoffmann model and the Ak ep parameter was used as a measure of tumor perfusion/permeability. Lactate was not detected in the smallest AT tumors (Group 1; 100-270mm 3). In larger AT tumors, the lactate concentration increased from 2.8±1.0mm (Group 2; 290-700mm 3) to 8.4±2.9mm (Group 3; 1000-1340mm 3) and 8.2±2.2mm (Group 4; 1380-1750mm 3), and then decreased to 5.0±1.7mm (Group 5; 1900-2500mm 3), and was consistently higher in the tumor core than in the rim. Lactate was not detected in any of the H tumors. The mean tumor Ak ep values decreased with increasing volume in both tumor types, but were significantly higher in H tumors. In AT tumors, the Ak ep values were significantly higher in the rim than in the core. Histological hypoxic and necrotic fractions in AT tumors increased with volume from 0% in Group 1 to about 20% and 30%, respectively, in Group 5. Minimal amounts of hypoxia and necrosis were found in H tumors of all sizes. Thus, the presence of lactate and heterogeneous perfusion/permeability are signatures of aggressive, metabolically deprived tumors. © 2011 John Wiley & Sons, Ltd.
Keywords: immunohistochemistry; controlled study; histopathology; nonhuman; gadolinium; nuclear magnetic resonance imaging; animal tissue; tumor volume; animal experiment; animal model; tumor marker; prostate cancer; hypoxia; prostate; tumors; contrast enhancement; rat; cancer size; rattus; acetic acid; dce-mri; lactic acid; permeability; tissue perfusion; quantum theory; sel-mqc; mrsi; lactate; dce mri; dunning r3327-at; dunning r3327-h
Journal Title: NMR in Biomedicine
Volume: 25
Issue: 1
ISSN: 0952-3480
Publisher: John Wiley & Sons  
Date Published: 2012-01-01
Start Page: 113
End Page: 122
Language: English
DOI: 10.1002/nbm.1723
PROVIDER: scopus
PUBMED: 21618306
PMCID: PMC3985132
DOI/URL:
Notes: --- - "Export Date: 1 March 2012" - "CODEN: NMRBE" - "Source: Scopus"
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MSK Authors
  1. Sunitha Bai Thakur
    91 Thakur
  2. Kristen L Zakian
    82 Zakian
  3. Jason A Koutcher
    275 Koutcher
  4. Sean Denis Carlin
    83 Carlin
  5. Howard T Thaler
    245 Thaler
  6. Asif Rizwan
    9 Rizwan
  7. Mihaela E Lupu
    10 Lupu
  8. Ya Wang
    20 Wang
  9. Cornelia Matei
    35 Matei