In vivo lactate signal enhancement using binomial spectral-selective pulses in selective MQ coherence (SS-SelMQC) spectroscopy Journal Article
| Authors: | Thakur, S. B.; Yaligar, J.; Koutcher, J. A. |
| Article Title: | In vivo lactate signal enhancement using binomial spectral-selective pulses in selective MQ coherence (SS-SelMQC) spectroscopy |
| Abstract: | Tumor vasculature and tissue oxygen pressure can influence tumor growth, metastases, and patient survival. Elevated levels of lactate may be observed during the process of aggressive tumor development accompanied by angiogenesis (the evolution of the microenvironment). The noninvasive MR detection of lactate in tumor tissues as a potential biomarker is difficult due to the presence of co-resonating lipids that are present at high concentrations. Methods were previously reported for lactate editing using the SELective Multiple Quantum Coherence (SelMQC) method. Here we report a sequence "SS-SelMQC," Spectral-Selective SelMQC, which is a modified version of SelMQC using binomial pulses. Binomial pulses were employed in this editing sequence for frequency excitation or inversion of selective lactate resonances. Lactate detection has been demonstrated using SS-SelMQC, both in vitro (30 mM lactate/H<sub>2</sub>O doped with 25 μM Gd-DTPA) and in vivo (Dunning R3337-AT prostate tumors), and compared to similar measurements made with SelMQC. Lactate areas were measured from nonlocalized spectra, one-dimensional (1D) localized spectra, and two-dimensional chemical shift images (CSI) of the localized slice. In data from whole phantoms, the modified pulse sequence yielded enhancement of the lactate signal of 2.4 ± 0.40 times compared to SelMQC. Similar in vivo lactate signal enhancement of 2.3 ± 0.24 times was observed in 1D slice-localized experiment. © 2009 Wiley-Liss, Inc. |
| Keywords: | controlled study; nonhuman; sensitivity and specificity; reproducibility of results; animal cell; animals; tumor localization; tumor volume; tumor markers, biological; lipid; animal model; in vivo study; in vitro study; cell line, tumor; algorithms; prostatic neoplasms; contrast enhancement; prostate tumor; rat; measurement; magnetic resonance spectroscopy; nuclear magnetic resonance spectroscopy; rats; phantom; water; gadolinium pentetate; signal processing; signal processing, computer-assisted; spectroscopy; signal detection; nuclear magnetic resonance; proton nuclear magnetic resonance; 2d chemical shift imaging; lactate editing; single-scan lipid suppression; spectral-selective binomial pulses; lactic acid; binomial distribution; frequency modulation; nuclear magnetic resonance scanner; spectral selective pulses in selective mq coherence spectroscopy; spectrometer |
| Journal Title: | Magnetic Resonance in Medicine |
| Volume: | 62 |
| Issue: | 3 |
| ISSN: | 0740-3194 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2009-09-01 |
| Start Page: | 591 |
| End Page: | 598 |
| Language: | English |
| DOI: | 10.1002/mrm.22065 |
| PUBMED: | 19526486 |
| PROVIDER: | scopus |
| PMCID: | PMC3071022 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: MRMEE" - "Source: Scopus" |
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