NCI, NHLBI/PBMTC First International Conference on late effects after pediatric hematopoietic cell transplantation: Persistent immune deficiency in pediatric transplant survivors Journal Article
| Authors: | Bunin, N.; Small, T.; Szabolcs, P.; Baker, K. S.; Pulsipher, M. A.; Torgerson, T. |
| Article Title: | NCI, NHLBI/PBMTC First International Conference on late effects after pediatric hematopoietic cell transplantation: Persistent immune deficiency in pediatric transplant survivors |
| Abstract: | Defective immune reconstitution is a major barrier to successful hematopoietic cell transplantation (HCT), and has important implications in the pediatric population. There are many factors that affect immune recovery, including stem cell source and graft-versus-host disease (GVHD). Complete assessment of immune recovery, including T and B lymphocyte evaluation, innate immunity, and response to neoantigens, may provide insight as to infection risk and optimal time for immunizations. The increasing use of cord blood grafts requires additional study regarding early reconstitution and impact upon survival. Immunization schedules may require modification based upon stem cell source and immune reconstitution, and this is of particular importance as many children have been incompletely immunized, or not at all, before school entry. Additional studies are needed in children post-HCT to evaluate the impact of differing stem cell sources upon immune reconstitution, infectious risks, and immunization responses. © 2012 American Society for Blood and Marrow Transplantation. |
| Keywords: | survival; child; treatment failure; hepatitis b; t lymphocyte; immune system; clinical assessment; hematopoietic stem cell transplantation; prediction; survivor; late effects; b lymphocyte; stem cell; cord blood stem cell transplantation; fetal blood; donor; clinical evaluation; graft versus host reaction; innate immunity; immune deficiency; graft vs host disease; hepatitis b vaccine; convalescence; influenza vaccine; influenza; immunologic deficiency syndromes; chickenpox vaccine; chickenpox; diphtheria pertussis tetanus vaccine; meningococcus vaccine; meningococcosis; pertussis; opportunistic infection; diphtheria; immunization; tetanus; measles mumps rubella vaccine; immune reconstitution; measles; mumps; rubella; pediatric allogeneic transplantation; pediatric autologous transplantation; immunological parameters |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 18 |
| Issue: | 1 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-01-01 |
| Start Page: | 6 |
| End Page: | 15 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2011.11.014 |
| PROVIDER: | scopus |
| PMCID: | PMC3253930 |
| PUBMED: | 22100979 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2012" - "CODEN: BBMTF" - "Source: Scopus" |
