| Abstract: |
(from the chapter) Structural and functional neuroimaging techniques provide a unique opportunity to examine the neural basis for cognitive changes related to cancer and its treatment. While the link between cognitive dysfunction and central nervous system (CNS) cancers (e.g., primary brain tumors, primary CNS lymphoma, brain metastases of cancer in other organ systems, etc.) or non-CNS cancers treated with prophylactic whole-brain radiation seems clear, our understanding of the causes for cognitive changes following chemotherapy for other non-CNS cancers remains much more limited. Research using a variety of neuroimaging modalities has begun to delineate the brain mechanisms for cognitive changes related to cancer and chemotherapy, across a number of cancer subtypes. This chapter will briefly summarize the cognitive domains most likely to be affected following chemotherapy, review the available data relating cognitive performance and structural and functional neuroimaging changes in various cancer populations, and suggest avenues for future work in this area. (PsycINFO Database Record (c) 2010 APA, all rights reserved). |
