Germline and somatic testing for homologous repair deficiency in patients with prostate cancer (part 1 of 2) Journal Article

  


Authors: Armstrong, A. J.; Taylor, A.; Haffner, M. C.; Abida, W.; Bryce, A. H.; Karsh, L. I.; Tagawa, S. T.; Twardowski, P.; Serritella, A. V.; Lang, J. M.
Article Title: Germline and somatic testing for homologous repair deficiency in patients with prostate cancer (part 1 of 2)
Abstract: Background/Objectives: Unfortunately, not all metastatic castration resistant prostate cancer (mCRPC) patients receive available life-prolonging systemic therapies, emphasizing the need to optimize mCRPC treatment selections. Better guidelines are necessary to determine genetic testing in prostate cancer. Subjects/Methods: In this two-part expert opinion-based guide, we provide an expert consensus opinion on the utilization of germline and somatic testing to detect HRR alterations in patients with mCRPC. This guide was developed by a multidisciplinary expert panel that convened in 2023–2024, including representatives from medical oncology, urology, radiation oncology, pathology, medical genomics, and basic science. Results/Conclusion: We argue for the widespread adoption of germline testing in all patients with prostate cancer and for somatic mutations testing in patients at the time of recurrent/metastatic disease. In this first part, we review how genomic testing is performed. We also review how to overcome certain barriers to integrate genetic and biomarker testing into clinical practice. © The Author(s) 2024.
Keywords: somatic mutation; review; systemic therapy; clinical practice; biological marker; consensus; metastasis; radiotherapy; practice guideline; prostate cancer; prostate; radiation oncology; diagnosis; urology; clinical practice guideline; drug therapy; genetic screening; therapy; human
Journal Title: Prostate Cancer and Prostatic Diseases
ISSN: 13657852
Publisher: The Author(s) 2024  
Publication status: Online ahead of print
Date Published: 2024-01-01
Online Publication Date: 2024-01-01
Language: English
DOI: 10.1038/s41391-024-00901-4
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205391419&doi=10.1038%2fs41391-024-00901-4&partnerID=40&md5=38715cc1d1c49ec62b6648c13027ce9c
Notes: Review -- Source: Scopus
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