Therapeutic implications of homologous repair deficiency testing in patients with prostate cancer (Part 2 of 2) Journal Article

  


Authors: Serritella, A. V.; Taylor, A.; Haffner, M. C.; Abida, W.; Bryce, A.; Karsh, L. I.; Tagawa, S. T.; Twardowski, P.; Armstrong, A. J.; Lang, J. M.
Article Title: Therapeutic implications of homologous repair deficiency testing in patients with prostate cancer (Part 2 of 2)
Abstract: Background/Objectives: Unfortunately, not all metastatic castration-resistant prostate cancer (mCRPC) patients receive available life-prolonging systemic therapies, emphasizing the need to optimize mCRPC treatment selections. Better guidelines are necessary to determine genetic testing for prostate cancer. Subjects/Methods: In this two-part expert opinion-based guide, we provide an expert consensus opinion on the utilization of germline and somatic testing to detect HRR alterations in patients with mCRPC. This guide was developed by a multidisciplinary expert panel that convened in 2023-2024, including representatives from medical oncology, urology, radiation oncology, pathology, medical genomics, and basic science. Results/Conclusions: In this second part, we highlight how genetic testing can lead to improved, life-prolonging mCRPC therapeutic strategies based on a review of the recent phase III trials and subsequent regulatory approvals for PARP inhibitors in mCRPC. © The Author(s) 2024.
Keywords: review; systemic therapy; consensus; prostate cancer; prostate; radiation oncology; urology; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; clinical practice guideline; drug therapy; genetic screening; therapy; human; metastatic castration resistant prostate cancer
Journal Title: Prostate Cancer and Prostatic Diseases
ISSN: 13657852
Publisher: The Author(s) 2024  
Publication status: Online ahead of print
Date Published: 2024-01-01
Online Publication Date: 2024-01-01
Language: English
DOI: 10.1038/s41391-024-00887-z
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85205065796&doi=10.1038%2fs41391-024-00887-z&partnerID=40&md5=fc8a73fd2927ed57270864635b9b0d86
Notes: Review -- Source: Scopus
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