Refractory and Resistant Herpes Simplex Virus Mucocutaneous Infections in Immunocompromised Patients: Literature Review and Proposed Definitions for Use in Clinical Trials Journal Article
| Authors: | Chemaly, R. F.; Shafat, T.; Wald, A.; Kotton, C. N.; Papanicolaou, G.; Yong, M. K.; Miller, V.; Komatsu, T. E.; Mullick, C.; Hodowanec, A. C.; Westman, G.; Khawaja, F.; Birkmann, A.; Ljungman, P.; Forum, H. S. V. Resistance Working Grp Transplant Associated Viral Infections |
| Article Title: | Refractory and Resistant Herpes Simplex Virus Mucocutaneous Infections in Immunocompromised Patients: Literature Review and Proposed Definitions for Use in Clinical Trials |
| Abstract: | Herpes simplex virus (HSV) infection is one of the most prevalent viral infections worldwide. In general, host immunity is sufficient to clear viral shedding and recurrences, although it is insufficient to prevent subsequent virologic reactivations. In immunocompromised patients, prolonged and difficult-to-treat HSV infections may develop. The diagnosis of refractory HSV infection is based on the lack of clinical response to nucleoside analogs. Antiviral resistance is confirmed via genotypic and/or phenotypic testing. To provide consensus definitions of refractory and/or resistant (R/R) HSV mucocutaneous infections for clinical trial use, the HSV Resistance Working Group of the Transplant Associated Viral Infections Forum, which includes international clinicians, scientists, industry representatives, and regulatory officials, conducted a literature review of previously published data related to R/R HSV infections in immunocompromised patients. We propose definitions of R/R HSV mucocutaneous infections, which will be subject to re-evaluation and revision based on forthcoming data and future studies. The Herpes Simplex Virus (HSV) Resistance Working Group of the Transplant Associated Viral Infections Forum developed consensus definitions for resistant and refractory HSV infections in immunocompromised patients for use in clinical trials. |
| Keywords: | thymidine kinase; herpes simplex virus; resistance; immunosuppression; double-blind; stem-cell transplantation; drug-resistance; refractory; definitions; antiviral drugs; long-term acyclovir; genital herpes; genotypic characterization; primase inhibitor bay-57-1293; dna-polymerase genes |
| Journal Title: | Clinical Infectious Diseases |
| ISSN: | 1058-4838 |
| Publisher: | Oxford University Press |
| Publication status: | Online ahead of print |
| Date Published: | 2025-01-01 |
| Online Publication Date: | 2025-01-01 |
| Language: | English |
| ACCESSION: | WOS:001407848700001 |
| DOI: | 10.1093/cid/ciae638 |
| PROVIDER: | wos |
| Notes: | Review; Early Access -- Source: Wos |
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