Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections Journal Article
| Authors: | Balfour, H. H. Jr; Benson, C.; Braun, J.; Cassens, B.; Erice, A.; Friedman-Kien, A.; Klein, T.; Polsky, B.; Safrin, S. |
| Article Title: | Management of acyclovir-resistant herpes simplex and varicella-zoster virus infections |
| Abstract: | Persons with AIDS who have CD4+ counts ⩽100 and transplant patients, especially bone marrow allograft recipients, may experience clinically significant infections with acyclovir-resistant herpes simplex virus (HSV) or varicella-zoster virus (VZV). Patients who have received prior repeated acyclovir treatment appear to be at the highest risk of harboring acyclovir-resistant strains. Algorithms for the management of these infections were developed at a recent roundtable symposium. The consensus of the panelists was that treatment with foscarnet should be initiated within 7-10 days in patients suspected to have acyclovir-resistant HSV or VZV infections. Foscarnet therapy should be continued for at least 10 days or until lesions are completely healed. Recurrences may respond to either foscarnet or, occasionally, acyclovir. © 1994 Raven Press, Ltd., New York. |
| Keywords: | adult; controlled study; clinical trial; review; dose response; controlled clinical trial; nephrotoxicity; randomized controlled trial; recurrence; aciclovir; herpes simplex; herpes zoster; drug effect; algorithms; simplexvirus; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; drug blood level; cd4 antigen; immunocompromised host; bone marrow transplantation; virus strain; foscarnet; t lymphocyte subpopulation; chickenpox; intravenous drug administration; vidarabine; resistance; antiviral activity; acyclovir; oral drug administration; zidovudine; herpesviridae infections; herpes simplex virus 2; varicella zoster virus; herpesvirus 3, human; drug resistance, microbial; humans; human; male; female; priority journal; virus resistance; herpes simplex virus (hsv); varicella-zoster virus (vzv); trifluridine |
| Journal Title: | JAIDS: Journal of Acquired Immune Deficiency Syndromes |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1525-4135 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1994-03-01 |
| Start Page: | 254 |
| End Page: | 260 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 8106965 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
