Three-dimensional rosettes in epithelial formation Journal Article
| Authors: | Neahring, L.; Zallen, J. A. |
| Article Title: | Three-dimensional rosettes in epithelial formation |
| Abstract: | Epithelia are ubiquitous tissues with essential structural, signaling, and barrier functions. How cells transition from individual to collective behaviors as they build and remodel epithelia throughout development is a fundamental question in developmental biology. Recent studies show that three-dimensional multicellular rosettes are key intermediates that provide a solution to the challenge of building tissue-scale epithelia by coordinating local interactions in small groups of cells. These radially polarized rosette structures facilitate epithelial formation by providing a protected environment for cells to acquire apical-basal polarity, establish cell adhesion, and coordinate intercellular signaling. Once formed, rosettes can dynamically expand, move, coalesce, and interact with surrounding tissues to generate a wide range of structures with specialized functions, including epithelial sheets, tubes, cavities, and branched networks. In this review, we describe the mechanisms that regulate rosette assembly and dynamics, and discuss how rosettes serve as versatile intermediates in epithelial morphogenesis. In addition, we present open questions about the molecular, cellular, and biophysical mechanisms that drive rosette behaviors, and discuss the implications of this widely used mode of epithelial formation for understanding embryonic development and human disease. © 2025 The Authors |
| Keywords: | cell adhesion; apical-basal polarity; mesenchymal-epithelial transition; epithelial morphogenesis; lumenogenesis; myosin contractility; rosette |
| Journal Title: | Cells and Development |
| ISSN: | 2667-291X |
| Publisher: | Elsevier Ireland Ltd. |
| Publication status: | Online ahead of print |
| Date Published: | 2025-03-20 |
| Online Publication Date: | 2025-03-20 |
| Start Page: | 204022 |
| Language: | English |
| DOI: | 10.1016/j.cdev.2025.204022 |
| PROVIDER: | scopus |
| PUBMED: | 40120722 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Jennifer Zallen -- Source: Scopus |
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