Waste as an antibacterial weapon Editorial
| Authors: | Elgrail, M. M.; Glickman, M. S. |
| Title: | Waste as an antibacterial weapon |
| Abstract: | Intracellular pathogens neutralize and evade macrophage-intrinsic host defenses. In this issue of Cell Host & Microbe, Anaya-Sanchez et al. show that methylglyoxal, a metabolic byproduct of glycolysis, is part of the macrophage arsenal limiting L. monocytogenes and M. tuberculosis infections but is countered by pathogen expression of methylglyoxal detoxification enzymes. © 2025 Elsevier Inc. |
| Keywords: | unclassified drug; nonhuman; note; chromosome mutation; animal; metabolism; animals; dna damage; immunology; antiinfective agent; mycobacterium tuberculosis; anti-bacterial agents; gamma interferon; cellular distribution; detoxification; pathogenicity; bacterial genome; microbiology; macrophage; macrophages; infection control; phagosome; glycolysis; lyase; listeriosis; listeria monocytogenes; tuberculosis; host pathogen interaction; enzyme; bacterial metabolism; chromosome damage; host-pathogen interactions; hexokinase; hexokinase 2; humans; human; methylglyoxal; pyruvaldehyde; glob protein; lactoylglutathione lyase |
| Journal Title: | Cell Host & Microbe |
| Volume: | 33 |
| Issue: | 7 |
| ISSN: | 1931-3128 |
| Publisher: | Cell Press |
| Date Published: | 2025-07-09 |
| Start Page: | 1045 |
| End Page: | 1047 |
| Language: | English |
| DOI: | 10.1016/j.chom.2025.06.011 |
| PUBMED: | 40639332 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
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