Role of tumor necrosis factor in the regulation of the inflammatory response of monocytes and macrophages Journal Article

  


Author: Yarilin, D. A.
Article Title: Role of tumor necrosis factor in the regulation of the inflammatory response of monocytes and macrophages
Abstract: Tumor necrosis factor (TNF) plays a key role in a host defense against various pathogens. Dysregulation of mechanisms that control inflammatory response may lead to development of chronic diseases. Monocytes and macrophages are actively involved in inflammation. Macrophage phenotypes exhibit considerable plasticity and evolve in response environmental changes. In this review, we will focus on molecular mechanisms that mediate TNF action during chronic inflammation. Such mechanisms that sustain temporal activation of signaling pathways and transcription factors after the initial transient response to TNF are important for understanding the role of TNF in pathogenesis of chronic inflammatory diseases including rheumatoid arthritis and for development of new therapies targeting specific molecules and pathways downstream of TNF as an alternative approach to total TNF blockade.
Keywords: inflammation; tnf; rheumatoid arthritis; monocytes; macrophages; tnf signaling blockade
Journal Title: Immunologiya
Volume: 35
Issue: 4
ISSN: 0206-4952
Publisher: Meditsina Publishers  
Date Published: 2014-01-01
Start Page: 195
End Page: 201
Language: Russian
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84990853015&partnerID=40&md5=5a5939ba54a3c8879eef0bbf351747d8
Notes: Article -- Export Date: 2 November 2016 -- Source: Scopus