| Abstract: |
Knowledge of genes associated with cancer risk provides important clinical opportunities for early detection and prevention of common and rare forms of human malignancies. Hereditary cancer syndromes often involve multiple organ systems, multifocal tumors, and/or early ages of disease-onset. The underlying cause of a syndrome can increasingly be identified with molecular genetic testing. Predictive testing of at-risk relatives can then guide their preventive management. Medical, surgical, and pediatric oncologists, genetics specialists, and other professionals are leading the integration of genetic testing into preventive and personalized oncology. Since genetic sequencing of tumors to target treatment will also reveal inherited predispositions, an understanding of preventive aspects of cancer genomics will become essential for every cancer care provider. This chapter reviews the common syndromes of hereditary cancer susceptibility, as well as established and emerging clinical applications of genetic testing. © 2018 The American Cancer Society. All rights reserved. |
| Keywords: |
breast cancer; genes; oncology; dna; tumors; mismatch repair; molecular biology; diseases; genetic testing; ovarian cancers; clinical genetics; (clinical) genetic testing; (colorectal) polyposis syndromes (apc, mutyh); dna mismatch repair deficiency (syndromes) (mlh1, msh2, msh6, pms2, epcam/tacstd1); hereditary (familial) cancer syndromes; hereditary (familial) colon (colorectal) cancer; hereditary (familial) gynecologic (endometrial, uterine, ovarian) cancer; hereditary (inherited) predisposition to cancer; hereditary breast and ovarian cancer syndrome (brca1, brca2); hereditary colorectal cancer type x; hereditary kidney (renal) cancer syndromes; lynch syndrome (hereditary nonpolyposis colorectal cancer, hnpcc); (colorectal) polyposis syndrome (apc, mutyh); dna mismatch repair deficiency (syndrome) (mlh1, msh2, msh6, pms2, epcam/tacstd1); hereditary (familial) cancer syndrome; hereditary kidney (renal) cancer syndrome; hereditary non-polyposis colorectal cancers; lynch syndrome hereditary nonpolyposis colorectal cancer; renal cancers
|
