Hereditary colon cancer Journal Article

  


Authors: Mendelsohn, R. B.; Markowitz, A. J.
Article Title: Hereditary colon cancer
Abstract: Colorectal cancer (CRC) remains one of the most common cancers in the world, and approximately 5-10 % of cases can be attributed to hereditary syndromes, including familial adenomatous polyposis, Lynch syndrome, MYH-associated polyposis, the hamartomatous syndromes, and their variants. Extensive research has identified the genes associated with many of these syndromes. Screening and management of patients with these conditions differs from that of the general population, and genetic testing and counselling has become crucial in this process. In this review, we discuss the different hereditary polyposis syndromes and their genetics, and emphasise approaches to the screening and surveillance of patients in the hope of preventing the morbidity and mortality currently associated with CRC. © Touch Briefings 2011.
Keywords: cancer surgery; gene mutation; treatment indication; cancer prevention; gastrointestinal symptom; differential diagnosis; genetic association; genetic variability; acetylsalicylic acid; nonsteroid antiinflammatory agent; cancer classification; lynch syndrome; upper gastrointestinal tract; hereditary nonpolyposis colorectal cancer; familial adenomatous polyposis; hereditary colorectal cancer; polyposis; juvenile polyp; ursodeoxycholic acid; familial colon polyposis; peutz jeghers syndrome; attenuated familial adenomatous polyposis; hypocholesterolemic agent; familial colorectal cancer type x; hamartomatous polyposis syndromes; myh-associated polyposis; gastrointestinal polyposis; attenuated familial colon polyposis; hamartomatous polyposis syndrome; myh associated polyposis
Journal Title: European Gastroenterology and Hepatology Review
Volume: 7
Issue: 4
ISSN: 1758-3799
Publisher: Touch Briefings 2011  
Date Published: 2012-01-01
Start Page: 251
End Page: 256
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84875249600&partnerID=40&md5=2d17aa91ce1c1c533d86745fdfdd74d6
Notes: --- - "Export Date: 1 April 2013" - "Source: Scopus"