Genetic factors: Hereditary cancer predisposition syndromes Book Section
| Authors: | Walsh, M. F.; Cadoo, K.; Salo-Mullen, E. E.; Dubard-Gault, M.; Stadler, Z. K.; Offit, K. |
| Editors: | Niederhuber, J. E.; Armitage, J. O.; Kastan, M. B.; Doroshow, J. H.; Tepper, J. E. |
| Article/Chapter Title: | Genetic factors: Hereditary cancer predisposition syndromes |
| Abstract: | The hereditary burden of human cancer is composed of rare syndromes resulting in high risk for malignancies, often involving multiple organ systems, as well as more common genomic variants associated with a moderate risk for disease. The diagnosis of cancer predisposition syndromes can usually be confirmed with molecular genetic testing of patients based on clinical, pathologic, or family history indicators. Genetic testing can be extended to relatives as a predictive guide to their preventive management. This chapter will review the major syndromes of cancer predisposition, diagnosis, and management. Because tumor genomic analysis often includes a comparison with the inherited DNA sequence, targeted approaches to oncologic therapy also create opportunities for precision prevention in cancer-affected families. © 2020 Elsevier Inc. |
| Keywords: | cancer risk; genetic counseling; cancer predisposition syndromes; inherited cancer genetics; precision prevention; preventive oncology |
| Book Title: | Abeloff’s Clinical Oncology. 6th ed |
| ISBN: | 9780323476744 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Philadelphia, PA |
| Date Published: | 2020-01-01 |
| Start Page: | 180 |
| End Page: | 208.e11 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-47674-4.00013-x |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 13, part of "Section B: Genesis of Cancer" in "Part I: Science and Clinical Oncology" -- Export Date: 1 March 2022 -- Source: Scopus |
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788Offit -
389Stadler -
82Salo-Mullen -
113Cadoo -
156Walsh
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