Radiances of Cerenkov-emitting radionuclides on the in vivo imaging system Journal Article

   


Authors: Pratt, E. C.; Shaffer, T. M.; Bauer, D.; Lewis, J. S.; Grimm, J.
Article Title: Radiances of Cerenkov-emitting radionuclides on the in vivo imaging system
Abstract: Cerenkov (or Cherenkov) luminescence occurs when charged particles exceed the phase velocity of a given medium. Cerenkov as a modality has gained interest for visualization of numerous radionuclides. However, reported Cerenkov intensities are limited or provided as theoretic fluence estimates. Here, we present the largest experimental dataset of Cerenkov-emitting radionuclides using the in vivo imaging system (IVIS Spectrum). We report Cerenkov radiances for 23 Cerenkov-emitting radionuclides, covering electrons, a-particles, and b-particles purified and in equilibrium where appropriate. Radionuclides measured include 11C, 18F, 32P, 47Sc, 52Mn, 64Cu, 67Cu, 68Ga, 72As, 76Br, 86Y, 89Zr, 90Y, 124I, 131I, 134Ce, 161Tb, 177Lu, 203Pb, 212Pb, 223Ra, 225Ac, and 227Th. These radiances allow experimental comparisons of radionuclides in Cerenkov luminescence imaging studies in the visible emission window, alongside minimum detectable activity concentrations. Lastly, these values greatly agree with prior theoretic modeling estimates. COPYRIGHT ß 2025 by the Society of Nuclear Medicine and Molecular Imaging.
Keywords: nonhuman; radiation dose; mouse; animal; animals; mice; radiotherapy; radiation exposure; irradiation; radioisotope; radioisotopes; fluorescence imaging; limit of detection; optical imaging; radionuclide therapy; cerenkov luminescence; article; radiance
Journal Title: Journal of Nuclear Medicine
Volume: 66
Issue: 5
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2025-05-01
Start Page: 817
End Page: 821
Language: English
DOI: 10.2967/jnumed.124.268806
PUBMED: 40081951
PROVIDER: scopus
PMCID: PMC12051767
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004005503&doi=10.2967%2fjnumed.124.268806&partnerID=40&md5=c44c09d6bafa87a9307c0e0fad42cd50
Notes: Article -- MSK corresponding author is Edwin Pratt -- Source: Scopus
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MSK Authors
  1. Jan Grimm
    93 Grimm
  2. Jason S Lewis
    456 Lewis
  3. Travis Michael Shaffer
    16 Shaffer
  4. Edwin C Pratt
    20 Pratt
  5. David Dieter Bauer
    13 Bauer
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