Safety and efficacy of transarterial therapies for pancreatic acinar cell carcinoma metastases Journal Article

  


Authors: Blume, H.; Petre, E. N.; Ziv, E.; Yuan, G.; Rodriguez, L.; Sotirchos, V.; Zhao, K.; Alexander, E. S.
Article Title: Safety and efficacy of transarterial therapies for pancreatic acinar cell carcinoma metastases
Abstract: Purpose: To evaluate the safety and efficacy of transarterial therapy, including hepatic arterial embolization (HAE) and transarterial radioembolization (TARE), for patients with hepatic metastases secondary to pancreatic acinar cell carcinoma (PACC). Methods: This retrospective, single-center study included patients with PACC liver metastases treated with transarterial therapy between 11/2013 and 2/2023. Nine patients with PACC were treated in a total of 18 sessions [HAE (n = 14), and TARE (n = 4)]. Patient demographics, tumor characteristics, and radiographic response were recorded. Local tumor progression-free survival (LTPFS) and overall survival (OS) were assessed via Kaplan-Meier analysis. Adverse events were graded according to Common Terminology Criteria for Adverse Events (CTCAE) v5. Results: Median LTPFS was 6.77 months (95 % CI: 3.23–26.33 months) after first treatment. Median assisted LTPFS in the six patients with multiple treatment sessions was 22.33 months (95 % CI: 3.67–31.93 months). Median OS was not reached (95 % CI: 0.17-NR). One-year OS from first treatment was 66.67 % (95 % CI: 28.17–87.83 %). Adverse events within one month of treatment occurred in 5/18 (27.8 %) sessions. Three of the five (60 %) reported complications were grade 1 and included mild post-embolization syndrome. One grade 3 complication occurred; pulmonary embolism associated with hypoxia and treated with anticoagulation. There was one death, grade 5, five days after treatment in a patient with a history of pancreaticoduodenectomy who developed a hepatic abscess complicated by sepsis. Conclusion: This small retrospective study suggests that transarterial therapies for PACC provide acceptable local control and safety. © 2025 Elsevier Inc.
Keywords: clinical article; controlled study; treatment response; aged; overall survival; cancer patient; nuclear magnetic resonance imaging; pancreaticoduodenectomy; progression free survival; computer assisted tomography; cohort analysis; anticoagulant therapy; retrospective study; hypoxia; lung embolism; confidence interval; liver metastasis; death; interventional radiology; sepsis; therapy effect; safety; kaplan meier method; patient treatment; liver abscess; anticoagulant agent; cell carcinoma; embolization; hepatic arterial embolization; adverse event; complication; polyvinyl alcohol; demographics; bland embolization; radioembolization; arterial embolization; pancreatic acinar cell carcinoma; acinar cell carcinoma of the pancreas; human; male; female; article; transarterial embolization; patient history of surgery; transarterial therapy; local progression free survival; post embolization syndrome; local tumor progressions; pancreatic acinar cells
Journal Title: Clinical Imaging
Volume: 121
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2025-04-30
Start Page: 110463
Language: English
DOI: 10.1016/j.clinimag.2025.110463
PROVIDER: scopus
PUBMED: 40163953
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105001131799&doi=10.1016%2fj.clinimag.2025.110463&partnerID=40&md5=6de445c4c87ba9df134037b4aaebdd06
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Erica Alexander -- Source: Scopus
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MSK Authors
  1. Elena Nadia Petre
    108 Petre
  2. Etay Ziv
    111 Ziv
  3. Vlasios S Sotirchos
    53 Sotirchos
  4. Erica Alexander
    36 Alexander
  5. Ken Zhao
    35 Zhao
  6. Lee Anthony Rodriguez
    13 Rodriguez
  7. Harrison Blume
    2 Blume
  8. Gavin Yuan
    3 Yuan
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