Outcomes of Y90 radioembolization for hepatocellular carcinoma in patients previously treated with transarterial embolization Journal Article
| Authors: | Zhao, K.; Son, S.; Karimi, A.; Marinelli, B.; Erinjeri, J. P.; Alexander, E. S.; Sotirchos, V. S.; Harding, J. J.; Soares, K. C.; Ziv, E.; Covey, A.; Sofocleous, C. T.; Yarmohammadi, H. |
| Article Title: | Outcomes of Y90 radioembolization for hepatocellular carcinoma in patients previously treated with transarterial embolization |
| Abstract: | The aim of this study was to evaluate outcomes of transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC) in patients previously treated with transarterial embolization (TAE). In this retrospective study, all HCC patients who received TARE from 1/2012 to 12/2022 for treatment of residual or recurrent disease after TAE were identified. Overall survival (OS) was estimated using the Kaplan–Meier method. Univariate Cox regression was performed to determine significant predictors of OS after TARE. Twenty-one patients (median age 73.4 years, 18 male, 3 female) were included. Median dose to the perfused liver volume was 121 Gy (112–444, range), and 18/21 (85.7%) patients received 112–140 Gy. Median OS from time of HCC diagnosis was 32.9 months (19.4–61.4, 95% CI). Median OS after first TAE was 29.3 months (15.3–58.9, 95% CI). Median OS after first TARE was 10.6 months (6.8–27.0, 95% CI). ECOG performance status of 0 (p = 0.038), index tumor diameter < 4 cm (p = 0.022), and hepatic tumor burden < 25% (p = 0.018) were significant predictors of longer OS after TARE. TARE may provide a survival benefit for appropriately selected patients with HCC who have been previously treated with TAE. © 2024 by the authors. |
| Keywords: | adult; clinical article; controlled study; treatment outcome; aged; aged, 80 and over; middle aged; retrospective studies; overall survival; hepatocellular carcinoma; ascites; liver cell carcinoma; liver cirrhosis; carcinoma, hepatocellular; liver neoplasms; nuclear magnetic resonance imaging; outcome assessment; follow up; progression free survival; computer assisted tomography; nephrotoxicity; radiotherapy; cohort analysis; retrospective study; alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; electronic medical record; tumor burden; dosimetry; liver tumor; radiation measurement; medronate technetium tc 99m; clinical evaluation; interdisciplinary communication; contrast medium; cross-sectional study; blood cell count; liver function test; kaplan meier method; radiofrequency ablation; hepatic artery embolization; therapy; yttrium; embolization, therapeutic; yttrium radioisotopes; angiography; platelet count; alpha fetoprotein; erythrocyte count; microsphere; yttrium 90; procedures; extravasation; radioembolization; paracentesis; response evaluation criteria in solid tumors; yttrium-90; child pugh score; very elderly; humans; human; male; female; article; leukocyte differential count; transarterial embolization; electronic health record; interventional radiologist; artificial embolization; ecog performance status; single photon emission computed tomography-computed tomography; microwave thermotherapy; local progression free survival; arterial venous shunt; bclc staging system; contrast enhanced cross sectional imaging; distal arterial occlusion; hepatic tumor burden; index tumor diameter; liver imaging reporting and data system 5 lesion; lung shunt fraction; macrovascular invasion; mapping angiography; medical internal radiation dose; perfused liver volume; single institution study; tumor distribution; univariate cox regression analysis |
| Journal Title: | Current Oncology |
| Volume: | 31 |
| Issue: | 5 |
| ISSN: | 1198-0052 |
| Publisher: | Multimed Inc |
| Date Published: | 2024-05-01 |
| Start Page: | 2650 |
| End Page: | 2661 |
| Language: | English |
| DOI: | 10.3390/curroncol31050200 |
| PUBMED: | 38785481 |
| PROVIDER: | scopus |
| PMCID: | PMC11120081 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Ken Zhao -- Source: Scopus |
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