TP53 mutation predicts worse survival and earlier local progression in patients with hepatocellular carcinoma treated with transarterial embolization Journal Article
| Authors: | Zhao, K.; Karimi, A.; Kelly, L.; Petre, E.; Marinelli, B.; Alexander, E. S.; Sotirchos, V. S.; Erinjeri, J. P.; Covey, A.; Sofocleous, C. T.; Harding, J. J.; Jarnagin, W.; Sigel, C.; Vakiani, E.; Ziv, E.; Yarmohammadi, H. |
| Article Title: | TP53 mutation predicts worse survival and earlier local progression in patients with hepatocellular carcinoma treated with transarterial embolization |
| Abstract: | The aim of this study was to evaluate associations between TP53 status and outcomes after transarterial embolization (TAE) for the treatment of patients with hepatocellular carcinoma (HCC). This single-institution study included patients from 1/2014 to 6/2022 who underwent TAE of HCC and genomic analysis of tumoral tissue. The primary outcome was overall survival (OS) with relation to TP53 status, and the secondary outcome was the time to progression. Survival analysis was performed using the Kaplan–Meier method. The time to progression with death or the last patient contact without progression as competing risks were used to obtain a cumulative incidence function, and the association with TP53 status was evaluated using the Gray test. In total, 75 patients (63 men) with a median age of 70.0 (IQR 62.0–76.3) years were included. Of these, 26/75 (34.7%) patients had TP53-mutant HCC. Patients with TP53-mutant HCC had a significantly worse median OS of 15.2 (95% CI, 9.5–29.3) months, versus 31.2 (95% CI, 21.2–52.4) months as the median OS (p = 0.023) for TP53 wild-type HCC. Competing risk analysis showed a shorter time to local hepatic progression (at the site of the previously treated tumor) after TAE in patients with TP53-mutant HCC. The cumulative incidences of local progression at 6 and 12 months for TP53-mutant HCC were 65.4% and 84.6%, versus 40.8% and 55.1% for TP53 wild-type HCC (p = 0.0072). A TP53 mutation may predict a worse overall survival and a shorter time to local progression in HCC patients treated with TAE. © 2025 by the authors. |
| Keywords: | adult; cancer survival; human tissue; aged; gene mutation; major clinical study; overall survival; hepatocellular carcinoma; cancer growth; chemoembolization; hepatitis b; hepatitis c; liver cell carcinoma; cancer staging; nuclear magnetic resonance imaging; outcome assessment; prospective study; genetic analysis; computer assisted tomography; cohort analysis; retrospective study; protein p53; bilirubin; electronic medical record; disease exacerbation; particle size; alpha fetoprotein; interventional oncology; arterial embolization; high throughput sequencing; human; male; female; article; transarterial embolization; ecog performance status; tumor protein p53 |
| Journal Title: | Current Oncology |
| Volume: | 32 |
| Issue: | 1 |
| ISSN: | 1198-0052 |
| Publisher: | Multimed Inc |
| Date Published: | 2025-01-01 |
| Start Page: | 51 |
| Language: | English |
| DOI: | 10.3390/curroncol32010051 |
| PROVIDER: | scopus |
| PMCID: | PMC11764326 |
| PUBMED: | 39851967 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Ken Zhao -- Source: Scopus |
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