Safety and efficacy of hepatic artery embolization in treating solitary fibrous tumor metastatic to the liver Journal Article

Authors: Velayati, S.; Erinjeri, J. P.; Brody, L. A.; Ziv, E.; Boas, F. E.; Brown, K. T.; Covey, A. M.; Getrajdman, G. I.; Solomon, S. B.; Kingham, P. T.; Tap, W. D.; Jarnagin, W. R.; Yarmohammadi, H.
Article Title: Safety and efficacy of hepatic artery embolization in treating solitary fibrous tumor metastatic to the liver
Abstract: The aim of this study was to evaluate safety and survival following hepatic artery embolization (HAE) for metastatic solitary fibrous tumor (SFT) in the liver. All patients with SFT metastatic to liver treated with HAE were retrospectively analyzed. Tumor response was evaluated using mRECIST. Objective response, overall survival (OS), and progression-free survival (PFS) were evaluated using Kaplan-Meier and multivariate Cox proportional hazard ratio. Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0. Twelve patients (6 males and 6 females, mean age: 42.5 ± 13 years; 24-65) were treated with 33 embolizations. Anatomical sites of origin for SFT were the head and neck (n = 6; 50%), pelvis (n = 2), pleura (n = 2), retroperitoneal (n = 1), and thigh (n = 1). The median follow-up from first HAE was 4.5 years (3-7.9). 84% of the patients showed objective response [42% complete response (CR) plus 42% partial response (PR)] to HAE by mRECIST (95% CI, 60-99%). Patients with CR to HAE had significantly higher OS compared to others (p<0.02). The postembolization median OS was 4 years (95% CI, 2.3-5.2), and mean PFS, for intra-or extrahepatic progression of disease, was 6 months (95%, CI, 3.2-7.1). One patient developed pneumonia/sepsis and died 27 days postembolization, possibly not directly related to embolization. No grade III or IV adverse events were identified in the remaining patients. In conclusion, HAE for metastatic liver SFT is a relatively safe treatment option with high response rate and should be considered as a treatment option for metastatic liver SFT. In our cohort of patients with metastatic SFT to the liver, we observed a median OS of 4 years following HAE. Further studies are needed to confirm the efficacy of HAE. © 2019 Sara Velayati et al.
Journal Title: Sarcoma
Volume: 2019
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2019-09-03
Start Page: 3060658
Language: English
DOI: 10.1155/2019/3060658
PROVIDER: scopus
PMCID: PMC6745165
PUBMED: 31565028
Notes: Source: Scopus
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MSK Authors
  1. Anne Covey
    123 Covey
  2. William R Jarnagin
    612 Jarnagin
  3. T Peter Kingham
    305 Kingham
  4. Lynn Brody
    97 Brody
  5. Karen T Brown
    167 Brown
  6. Stephen Solomon
    278 Solomon
  7. Franz Edward Boas
    39 Boas
  8. Etay   Ziv
    32 Ziv