Comprehensive review of the utility of dynamic contrast-enhanced MRI for the diagnosis and treatment assessment of spinal benign and malignant osseous disease Review

  

Authors:	Saha, A.; Gibbs, H.; Peck, K. K.; Yildirim, O.; Nilchian, P.; Karimi, S.; Lis, E.; Kosović, V.; Holodny, A. I.
Review Title:	Comprehensive review of the utility of dynamic contrast-enhanced MRI for the diagnosis and treatment assessment of spinal benign and malignant osseous disease
Abstract:	Conventional MRI is currently the preferred imaging technique for detection and evaluation of malignant spinal lesions. However, this technique is limited in its ability to assess tumor viability. Unlike conventional MRI, dynamic contrast-enhanced (DCE) MRI provides insight into the physiologic and hemodynamic characteristics of malignant spinal tumors and has been utilized in different types of spinal diseases. DCE has been shown to be especially useful in the cancer setting; specifically, DCE can discriminate between malignant and benign vertebral compression fractures as well as between atypical hemangiomas and metastases. DCE has also been shown to differentiate between different types of metastases. Furthermore, DCE can be useful in the assessment of radiation therapy for spinal metastases, including the prediction of tumor recurrence. This review considers data analysis methods utilized in prior studies of DCE-MRI data acquisition and clinical implications. © 2025 American Society of Neuroradiology. All rights reserved.
Keywords:	middle aged; review; nuclear magnetic resonance imaging; magnetic resonance imaging; metastasis; radiotherapy; diagnostic imaging; prediction; image enhancement; tumor recurrence; diagnosis; spine; spinal neoplasms; contrast medium; contrast media; dynamic contrast-enhanced magnetic resonance imaging; therapy; hemodynamics; hemangioma; spinal cord lesion; spine metastasis; spine tumor; vertebra; spine disease; procedures; compression fracture; humans; human; spinal diseases; dynamic contrast enhanced imaging; mri scanner
Journal Title:	American Journal of Neuroradiology
Volume:	46
Issue:	3
ISSN:	0195-6108
Publisher:	American Society of Neuroradiology
Date Published:	2025-03-01
Start Page:	465
End Page:	475
Language:	English
DOI:	10.3174/ajnr.A8398
PUBMED:	39481890
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000672470&doi=10.3174%2fajnr.A8398&partnerID=40&md5=c4a6f896d6f6a544378cebc5dac77984
Notes:	Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Atin Shah -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/223678