Dynamic contrast-enhanced MRI perfusion for differentiating between melanoma and lung cancer brain metastases Journal Article
| Authors: | Hatzoglou, V.; Tisnado, J.; Mehta, A.; Peck, K. K.; Daras, M.; Omuro, A. M.; Beal, K.; Holodny, A. I. |
| Article Title: | Dynamic contrast-enhanced MRI perfusion for differentiating between melanoma and lung cancer brain metastases |
| Abstract: | Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI. Dynamic contrast-enhanced (DCE)-MRI can assess tumor microvasculature and has demonstrated utility in characterizing primary brain tumors. Our aim was to evaluate the performance of plasma volume (Vp) and volume transfer coefficient (Ktrans) derived from DCE-MRI in distinguishing between melanoma and nonsmall cell lung cancer (NSCLC) brain metastases. Forty-seven NSCLC and 23 melanoma brain metastases were retrospectively assessed with DCE-MRI. Regions of interest were manually drawn around the metastases to calculate Vpmean and Ktrans mean. The Mann–Whitney U test and receiver operating characteristic analysis (ROC) were performed to compare perfusion parameters between the two groups. The Vpmean of melanoma brain metastases (4.35, standard deviation [SD] = 1.31) was significantly higher (P = 0.03) than Vpmean of NSCLC brain metastases (2.27, SD = 0.96). The Ktrans mean values were higher in melanoma brain metastases, but the difference between the two groups was not significant (P = 0.12). Based on ROC analysis, a cut-off value of 3.02 for Vpmean (area under curve = 0.659 with SD = 0.074) distinguished between melanoma brain metastases and NSCLC brain metastases (P < 0.01) with 72% specificity. Our data show the DCE-MRI parameter Vpmean can differentiate between melanoma and NSCLC brain metastases. The ability to noninvasively predict tumor histology of brain metastases in patients with multiple malignancies can have important clinical implications. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
| Keywords: | neuroimaging; melanoma; non-small cell lung cancer; brain tumors; perfusion weighted mri |
| Journal Title: | Cancer Medicine |
| Volume: | 6 |
| Issue: | 4 |
| ISSN: | 2045-7634 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2017-01-01 |
| Start Page: | 761 |
| End Page: | 767 |
| Language: | English |
| DOI: | 10.1002/cam4.1046 |
| PROVIDER: | scopus |
| PMCID: | PMC5387174 |
| PUBMED: | 28303695 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2017 -- Source: Scopus |
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