Comparison of glioblastomas and brain metastases using dynamic contrast-enhanced perfusion MRI Journal Article

   

Authors:	Jung, B. C.; Arevalo-Perez, J.; Lyo, J. K.; Holodny, A. I.; Karimi, S.; Young, R. J.; Peck, K. K.
Article Title:	Comparison of glioblastomas and brain metastases using dynamic contrast-enhanced perfusion MRI
Abstract:	PURPOSE: To compare glioblastoma and brain metastases using T1-weighted dynamic contrast-enhanced (DCE)-MRI perfusion technique. METHODS: 26 patients with glioblastoma and 32 patients with metastatic brain lesions with no treatment who underwent DCE-MRI were, retrospectively, analyzed. DCE perfusion parameters Ktrans and Vp were calculated for the whole tumor. Signal intensity time curves were quantified by calculating the area under the curve (AUC) and the logarithmic slope of the washout phase to explore the heterogeneous tumor characteristics. RESULTS: Glioblastoma did not differ from all brain metastases in Ktrans (P = .34) or Vp (P = .47). Glioblastoma and melanoma metastases differed from hypovascular metastases in AUC and log slope of the washout phase of the signal intensity time curve (P < .05); however, glioblastoma and melanoma metastases did not differ from each other (AUC: P = .78, Log slope: P = .77). Glioblastoma and melanoma metastases differed from hypovascular metastases in the ratio of Voxelneg/Voxelpos (P< .03); however, they did not differ from each other. Glioblastoma and melanoma metastases differed from each other in Voxelneg_threshold at higher negative log slope threshold. CONCLUSION: DCE-MRI showed that it has a potential to differentiate glioblastomas, melanoma metastases and hypovascular brain tumors. Logarithmic slope of the washout phase and AUC of the signal intensity time curve were shown to be the best discriminator between hypervascular and hypovascular neoplasms. © 2016 American Society of Neuroimaging.
Keywords:	neoplasm; metastasis; brain; glioblastoma; dynamic contrast-enhanced (dce) mri
Journal Title:	Journal of Neuroimaging
Volume:	26
Issue:	2
ISSN:	1051-2284
Publisher:	Wiley Blackwell
Date Published:	2016-03-01
Start Page:	240
End Page:	246
Language:	English
DOI:	10.1111/jon.12281
PROVIDER:	scopus
PMCID:	PMC4753138
PUBMED:	26235208
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84959240098&partnerID=40&md5=ec65c3bf3c94fddb5dcc0fafa0d87849
Notes:	Article -- Export Date: 4 April 2016 -- Source: Scopus

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