Human papillomaviruses Book Section
| Author: | Esther Babady, N. |
| Editors: | Truant, A. L.; Tang, Y. W.; Waites, K. B.; Bébéar, C.; Rennie, R. P. |
| Article/Chapter Title: | Human papillomaviruses |
| Abstract: | Human papillomaviruses (HPVs) infect the epithelial cells of the skin and mucosal surfaces and cause a range of infections from asymptomatic to benign skin warts to invasive cervical cancer. Mucosal HPVs are classified as either low-risk (LR) or high-risk (HR) HPV types based on their oncogenic potential. Approximately 40 HPV types, both low- and high-risk HPVs, can infect mucosal membranes, resulting in warts (LR HPVs) or intraepithelial neoplasia and cancers (HR HPVs). Both low- and high-risk HPV types can cause abnormal cervical cytology. Abnormal cervical cytology diagnoses are reported as atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL) or high-grade squamous intraepithelial lesions (HSIL), and squamous cell carcinoma. In situ hybridization (ISH) allows for the direct visualization of target nucleic acids in tissues or cells through binding of labeled probes. Several HPV detection assays include a genotyping assay for HPV genotype 16 and 18 and/or additional HPV genotypes. © 2016 by John Wiley & Sons, Inc. All rights reserved. |
| Keywords: | in situ hybridization; nucleic acid amplification; squamous intraepithelial lesions; cervical cytology; atypical squamous cells; human papillomaviruses; high-risk hpv; low-risk hpv; mucosal hpvs |
| Book Title: | Manual of Commercial Methods in Clinical Microbiology: International Edition. 2nd ed |
| ISBN: | 978-111902187-2 |
| Publisher: | John Wiley & Sons |
| Publication Place: | Hoboken, NJ |
| Date Published: | 2016-01-01 |
| Start Page: | 135 |
| End Page: | 148 |
| Language: | English |
| DOI: | 10.1002/9781119021872.ch8 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 8 -- Source: Scopus |
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