Precursor Lesions of the Cervix: Squamous Precursor Lesions Book Section
| Author: | Park, K. J. |
| Article/Chapter Title: | Precursor Lesions of the Cervix: Squamous Precursor Lesions |
| Abstract: | Cervical squamous precursor lesions precede invasive carcinomas by 10–15 years and, therefore, are highly amenable to screening and early detection. This section reviews squamous intraepithelial lesions from low-grade to high-grade, as well as their benign and neoplastic morphologic mimics. Low-risk human papillomaviruses (HPV) cause condylomas and low-grade lesions characterized by productive viral infections with little to no risk for progression to carcinoma. High-risk HPV, on the other hand, causes low-grade and high-grade lesions with a significantly higher risk of progression to invasive carcinoma. The diagnostic reproducibility of CIN 1, CIN 2, and CIN 3 is only moderate at best and the use of ancillary studies to adjudicate difficult cases is encouraged in the appropriate setting. Immunohistochemistry for p16 and Ki-67 can be very helpful in the distinction between benign and high-grade intraepithelial lesions, yet these should not be used to differentiate benign from low-grade lesions. HPV in-situ hybridization (mRNA-based) is a highly sensitive and specific marker for the detection of HPV transcription in suspected lesions and is a useful addition to standard immunohistochemistry. Other neoplastic lesions, such as stratified mucin-producing intraepithelial lesion (SMILE) and metastatic urothelial carcinoma, can also mimic HSIL. Clinical history and careful examination of the histologic features are key to arriving at the correct diagnosis. © Springer Nature Switzerland AG 2021. |
| Keywords: | immunohistochemistry; medical imaging; screening; diagnosis; biochemistry; medical computing; low grade; biomedical engineering; biochemical engineering; in-situ hybridization; viral infections; precursor lesions; human papilloma virus; reproducibilities; high grades; morpho-logics; low-high |
| Book Title: | Atlas of Diagnostic Pathology of the Cervix: a Case-Based Approach |
| ISBN: | 978-303049954-9 |
| Publisher: | Springer |
| Date Published: | 2020-01-01 |
| Start Page: | 105 |
| End Page: | 124 |
| Language: | English |
| DOI: | 10.1007/978-3-030-49954-9_5 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter -- Source: Scopus |
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