Atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC-H): Does HPV matter? Journal Article

  


Authors: Reid-Nicholson, M.; Gatscha, R. M.; Riedel, E. R.; Lin, O.
Article Title: Atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC-H): Does HPV matter?
Abstract: The role of human papillomavirus (HPV) in cases diagnosed as atypical squamous cells, cannot exclude high squamous grade intraepithelial lesion (ASC-H) in cervical specimens is not well established. The objective of this study is to evaluate the role of HPV status in cases of ASC-H in a major cancer center. One hundred thirty-two patients with a diagnosis of ASC-H were identified over a 4-yr period in our institution. Forty-four of 132 cases were evaluated for high-risk HPV and had biopsy follow-up. The positive predictive value (PPV) of ASC-H for high-grade squamous intraepithelial lesions overall was 32% while PPV of ASC-H with associated HR HPV was 42%. This increase was statistically significant with P = 0.003 and suggest that HPV testing might be useful to increase the PPV of ASC-H. © 2006 Wiley-Liss, Inc.
Keywords: adolescent; adult; clinical article; human tissue; aged; aged, 80 and over; middle aged; retrospective studies; follow up; risk factors; retrospective study; prediction; high risk patient; cancer center; statistical significance; predictive value of tests; dna, viral; tumor virus infections; new york; uterine cervical neoplasms; cervix; uterine cervix cytology; wart virus; uterine cervix carcinoma in situ; cervical intraepithelial neoplasia; papillomavirus infections; uterine cervical dysplasia; vaginal smears; precancerous conditions; papillomaviridae; colposcopy asc-h; papillomavirus
Journal Title: Diagnostic Cytopathology
Volume: 35
Issue: 1
ISSN: 8755-1039
Publisher: Wiley Liss  
Date Published: 2007-01-01
Start Page: 1
End Page: 5
Language: English
DOI: 10.1002/dc.20576
PUBMED: 17173297
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33846251964&partnerID=40&md5=4a974253c939b76c6346a6ac143a2c1e
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: DICYE" - "Source: Scopus"
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MSK Authors
  1. Elyn Renee Stubblefield
    203 Stubblefield
  2. Oscar Lin
    307 Lin
  3. Michelle Dian Reid-Nicholson
    7 Reid-Nicholson
  4. Rose Marie Gatscha
    15 Gatscha
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