Author: | Studer, L. |
Title: | Identification of a chemical cocktail that drives the maturation of human neurons |
Abstract: | The protracted timeline of maturation is a major bottleneck in generating adult-like neurons from human pluripotent stem cells. We identify a combination of four chemicals that promotes neuronal maturation by repressing epigenetic factors that inhibit it and stimulating activity-dependent factors that promote it. |
Journal Title: | Nature Biotechnology |
Volume: | 42 |
Issue: | 10 |
ISSN: | 1087-0156 |
Publisher: | Nature Publishing Group |
Date Published: | 2024-10-01 |
Start Page: | 1502 |
End Page: | 1503 |
Language: | English |
ACCESSION: | WOS:001138166100017 |
DOI: | 10.1038/s41587-023-02044-8 |
PROVIDER: | wos |
PUBMED: | 38168997 |
Notes: | Source: Wos |