Epigenetic control and manipulation of neuronal maturation timing Review

  


Authors: Ciceri, G.; Studer, L.
Review Title: Epigenetic control and manipulation of neuronal maturation timing
Abstract: During brain development, the sequence of developmental steps and the underlying transcriptional regulatory logic are largely conserved across species. However, the temporal unfolding of developmental programs varies dramatically across species and within a given species varies across brain regions and cell identities. The maturation of neurons in the human cerebral cortex is particularly slow and lasts for many years compared with only a few weeks for the corresponding mouse neurons. The mechanisms setting the ‘schedule’ of neuronal maturation remain unclear but appear to be linked to a cell-intrinsic ‘clock’. Here, we discuss recent findings that highlight a role for epigenetic factors in the timing of neuronal maturation. Manipulations of those factors in stem cell-based models can override the intrinsic pace of neuronal maturation, including its protracted nature in human cortical neurons. We then contextualize the epigenetic regulation of maturation programs with findings from other model systems and propose potential interactions between epigenetic pathways and other drivers of developmental rates. © 2024 The Authors
Keywords: genetics; review; nonhuman; mouse; animal; metabolism; animals; mice; gene expression; brain cortex; neurons; physiology; stem cell; gene expression regulation; brain; epigenesis, genetic; brain development; fetus; nervous system development; neurogenesis; nerve cell; genetic epigenesis; brain region; maturation; brain cell; humans; human
Journal Title: Current Opinion in Genetics and Development
Volume: 85
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2024-04-01
Start Page: 102164
Language: English
DOI: 10.1016/j.gde.2024.102164
PUBMED: 38412562
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85186141178&doi=10.1016%2fj.gde.2024.102164&partnerID=40&md5=e5442dfa7bc79a2112df4d1807d48652
Notes: Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding authors are Gabriele Ciceri and Lorenz Studer -- Source: Scopus
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MSK Authors
  1. Lorenz Studer
    223 Studer
  2. Gabriele Ciceri
    13 Ciceri
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