Understanding risk factors for endometrial cancer in young women Journal Article

   


Authors: Peeri, N. C.; Bertrand, K. A.; Na, R.; De Vivo, I.; Setiawan, V. W.; Seshan, V. E.; Alemany, L.; Chen, Y.; Clarke, M. A.; Clendenen, T.; Cook, L. S.; Costas, L.; Dal Maso, L.; Freudenheim, J. L.; Friedenreich, C. M.; Gierach, G. L.; Goodman, M. T.; La Vecchia, C.; Levi, F.; Lopez-Querol, M.; Lu, L.; Moysich, K. B.; Mutter, G.; Naduparambil, J.; Negri, E.; O’Connell, K.; O’Mara, T.; Palmer, J. R.; Parazzini, F.; Penney, K. L.; Petruzella, S.; Reynolds, P.; Ricceri, F.; Risch, H.; Rohan, T. E.; Sacerdote, C.; Sandin, S.; Shu, X. O.; Stolzenberg-Solomon, R. Z.; Webb, P. M.; Wentzensen, N.; Wilkens, L. R.; Xu, W.; Yu, H.; Zeleniuch-Jacquotte, A.; Zheng, W.; Guo, X.; Lipworth, L.; Du, M.
Article Title: Understanding risk factors for endometrial cancer in young women
Abstract: Background: The American Cancer Society recommends physicians inform average-risk women about endometrial cancer risk on reaching menopause, but new diagnoses are rising fastest in women aged younger than 50 years. Educating these younger women about endometrial cancer risks requires knowledge of risk factors. However, endometrial cancer in young women is rare and challenging to study in single study populations. Methods: We included 13 846 incident endometrial cancer patients (1639 aged younger than 50 years) and 30 569 matched control individuals from the Epidemiology of Endometrial Cancer Consortium. We used generalized linear models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for 6 risk factors and endometrial cancer risk. We created a risk score to evaluate the combined associations and population attributable fractions for these factors. Results: In younger and older women, we observed positive associations with body mass index and diabetes and inverse associations with age at menarche, oral contraceptive use, and parity. Current smoking was associated with reduced risk only in women aged 50 years and older (Phet < .01). Body mass index was the strongest risk factor (OR≥ 35 vs <25 kg=m2 1⁄4 5.57, 95% CI 1⁄4 4.33 to 7.16, for ages younger than 50 years; OR≥ 35 vs <25 kg=m2 1⁄4 4.68, 95% CI 1⁄4 4.30 to 5.09, for ages 50 years and older; Phet 1⁄4 .14). Possessing at least 4 risk factors was associated with approximately ninefold increased risk in women aged younger than 50 years and approximately fourfold increased risk in women aged 50 years and older (Phet < .01). Together, 59.1% of endometrial cancer in women aged younger than 50 years and 55.6% in women aged 50 years and older were attributable to these factors. Conclusions: Our data confirm younger and older women share common endometrial cancer risk factors. Early educational efforts centered on these factors may help mitigate the rising endometrial cancer burden in young women. © The Author(s) 2024. Published by Oxford University Press. All rights reserved.
Keywords: adult; controlled study; aged; middle aged; young adult; major clinical study; case control study; case-control studies; cancer risk; united states; cancer patient; cancer incidence; endometrial neoplasms; endometrium cancer; cohort analysis; odds ratio; risk factors; smoking; age factors; risk factor; menarche; age; body mass; body mass index; education; diabetes mellitus; cancer epidemiology; epidemiology; menopause; endometrium tumor; oral contraceptive agent; etiology; adverse event; contraceptives, oral; parity; humans; human; female; article; oral contraceptive use; people by smoking status
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 117
Issue: 1
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 2025-01-01
Start Page: 76
End Page: 88
Language: English
DOI: 10.1093/jnci/djae210
PUBMED: 39235934
PROVIDER: scopus
PMCID: PMC11717423
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85214837355&doi=10.1093%2fjnci%2fdjae210&partnerID=40&md5=de72d6ed92d6c5b3c1f518f24d402443
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Mengmeng Du -- Source: Scopus
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MSK Authors
  1. Venkatraman Ennapadam Seshan
    385 Seshan
  2. Stacey Lee Petruzella
    26 Petruzella
  3. Mengmeng Du
    77 Du
  4. Kelli O'Connell
    50 O'Connell
  5. Noah Charles Peeri
    9 Peeri
  6. Jeffin Joe Naduparambil
    3 Naduparambil
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