Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2) Journal Article

   


Authors: Harvey, S. V.; Wentzensen, N.; Bertrand, K.; Black, A.; Brinton, L. A.; Chen, C.; Costas, L.; Dal Maso, L.; De Vivo, I.; Du, M.; Garcia-Closas, M.; Goodman, M. T.; Gorzelitz, J.; Johnson, L.; Lacey, J. V.; Liao, L.; Lipworth, L.; Lissowska, J.; Miller, A. B.; O'Connell, K.; O'Mara, T. A.; Ou, X.; Palmer, J. R.; Patel, A. V.; Paytubi, S.; Pelegrina, B.; Petruzella, S.; Prizment, A.; Rohan, T.; Sandin, S.; Setiawan, V. W.; Sinha, R.; Trabert, B.; Webb, P. M.; Wilkens, L. R.; Xu, W.; Yang, H. P.; Zheng, W.; Clarke, M. A.
Article Title: Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)
Abstract: BACKGROUND: Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18-21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). METHODS: We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. RESULTS: We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47-3.29) and young adulthood (OR = 1.26, 95% CI = 1.06-1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. CONCLUSIONS: Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts. Published by Oxford University Press on behalf of the International Epidemiological Association 2023.
Keywords: adult; young adult; endometrial cancer; endometrial neoplasms; risk factors; weight loss; obesity; risk factor; body mass; body mass index; epidemiology; endometrium tumor; life event; life change events; uterine cancer; weight gain; complication; bmi; weight change; body weight loss; humans; human; female; body weight gain; gynaecology; bmi change; life course exposures
Journal Title: International Journal of Epidemiology
Volume: 52
Issue: 4
ISSN: 0300-5771
Publisher: Oxford University Press  
Date Published: 2023-08-01
Start Page: 1086
End Page: 1099
Language: English
DOI: 10.1093/ije/dyad046
PUBMED: 37029916
PROVIDER: scopus
PMCID: PMC10396409
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85166442225&doi=10.1093%2fije%2fdyad046&partnerID=40&md5=daefe5c020808c4d56b85f19efae7179
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus
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MSK Authors
  1. Stacey Lee Petruzella
    26 Petruzella
  2. Mengmeng Du
    74 Du
  3. Kelli O'Connell
    44 O'Connell
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