Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: Influence of estrogen receptor status of the first breast cancer Journal Article


Authors: Brooks, J. D.; John, E. M.; Mellemkjær, L.; Lynch, C. F.; Knight, J. A.; Malone, K. E.; Reiner, A. S.; Bernstein, L.; Liang, X.; Shore, R. E.; Stovall, M.; WECARE Study Collaborative Group; Bernstein, J. L.
Contributors: Capanu, M.; Orlow, I.; Robson, M.; Woods, M.
Article Title: Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: Influence of estrogen receptor status of the first breast cancer
Abstract: Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)-negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer. The WECARE Study is a population-based case–control study of young women with CBC (cases, N = 1386) and with unilateral breast cancer (controls, N = 2045). Rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess the relationship between BMI and risk of CBC stratified by menopausal and ER status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an ER-negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of CBC (RR = 1.9, 95% CI: 1.02, 3.4). Also, weight gain of ≥10 kg after first diagnosis was associated with an almost twofold increased risk of CBC (RR = 1.9, 95% CI: 0.99, 3.8). These results suggest that women with an ER-negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of CBC. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Keywords: body mass index; estrogen receptor; contralateral breast cancer
Journal Title: Cancer Medicine
Volume: 5
Issue: 11
ISSN: 2045-7634
Publisher: Wiley Blackwell  
Date Published: 2016-11-01
Start Page: 3282
End Page: 3291
Language: English
DOI: 10.1002/cam4.890
PROVIDER: scopus
PMCID: PMC5119984
PUBMED: 27700016
DOI/URL:
Notes: Article -- Export Date: 6 December 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Anne S Reiner
    122 Reiner
  2. Mark E Robson
    368 Robson
  3. Irene Orlow
    192 Orlow
  4. Marinela Capanu
    211 Capanu
  5. Jonine L Bernstein
    104 Bernstein
  6. Xiaolin Liang
    41 Liang
  7. Meghan   Woods
    13 Woods