The etiology of uterine sarcomas: A pooled analysis of the epidemiology of endometrial cancer consortium Journal Article

Authors: Felix, A. S.; Cook, L. S.; Gaudet, M. M.; Rohan, T. E.; Schouten, L. J.; Setiawan, V. W.; Wise, L. A.; Anderson, K. E.; Bernstein, L.; De Vivo, I.; Friedenreich, C. M.; Gapstur, S. M.; Goldbohm, R. A.; Henderson, B.; Horn-Ross, P. L.; Kolonel, L.; Lacey, J. V.; Liang, X.; Lissowska, J.; Magliocco, A.; McCullough, M. L.; Miller, A. B.; Olson, S. H.; Palmer, J. R.; Park, Y.; Patel, A. V.; Prescott, J.; Rastogi, R.; Robien, K.; Rosenberg, L.; Schairer, C.; Ou Shu, X.; Van Den Brandt, P. A.; Virkus, R. A.; Wentzensen, N.; Xiang, Y. B.; Xu, W. H.; Yang, H. P.; Brinton, L. A.
Article Title: The etiology of uterine sarcomas: A pooled analysis of the epidemiology of endometrial cancer consortium
Abstract: Background: Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their aetiology is poorly understood. Therefore, we performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined risk factor associations for malignant mixed mullerian tumours (MMMTs) and endometrioid endometrial carcinomas (EECs) for comparison purposes. Methods: We pooled data on 229 uterine sarcomas, 244 MMMTs, 7623 EEC cases, and 28 829 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for risk factors associated with uterine sarcoma, MMMT, and EEC were estimated with polytomous logistic regression. We also examined associations between epidemiological factors and histological subtypes of uterine sarcoma. Results: Significant risk factors for uterine sarcoma included obesity (body mass index (BMI)≥30 vs BMI<25 kg m-2 (OR: 1.73, 95% CI: 1.22-2.46), P-trend=0.008) and history of diabetes (OR: 2.33, 95% CI: 1.41-3.83). Older age at menarche was inversely associated with uterine sarcoma risk (≥15 years vs <11 years (OR: 0.70, 95% CI: 0.34-1.44), P-trend: 0.04). BMI was significantly, but less strongly related to uterine sarcomas compared with EECs (OR: 3.03, 95% CI: 2.82-3.26) or MMMTs (OR: 2.25, 95% CI: 1.60-3.15, P-heterogeneity=0.01). Conclusion: In the largest aetiological study of uterine sarcomas, associations between menstrual, hormonal, and anthropometric risk factors and uterine sarcoma were similar to those identified for EEC. Further exploration of factors that might explain patterns of age-and race-specific incidence rates for uterine sarcoma are needed. © 2013 Cancer Research UK. All rights reserved.
Journal Title: British Journal of Cancer
Volume: 108
Issue: 3
ISSN: 0007-0920
Publisher: Nature Publishing Group  
Date Published: 2013-02-19
Start Page: 727
End Page: 734
Language: English
DOI: 10.1038/bjc.2013.2
PROVIDER: scopus
PMCID: PMC3593566
PUBMED: 23348519
Notes: --- - "Export Date: 1 April 2013" - "CODEN: BJCAA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Sara H Olson
    224 Olson
  2. Xiaolin Liang
    45 Liang
  3. Radhai Manickam Rastogi
    10 Rastogi