MicroRNA expression in high-grade B-cell lymphoma with 11q aberration Journal Article
| Authors: | Di Stefano, G.; Fischer, A.; Chteinberg, E.; Bens, S.; Wagener, R.; Abramov, D.; Adam, P.; Bernhart, S. H.; Borkhardt, A.; Burkhardt, B.; Del-Val, C.; Frühwald, M. C.; Guazzo, R.; Hoell, J. I.; Hummel, M.; Horn, H.; Klapper, W.; Krugmann, J.; Kurz, K. S.; Lazzi, S.; Louissaint, A. J.; Mottok, A.; Oschlies, I.; Santi, R.; Schafernak, K.; Staiger, A. M.; Zhang, Y.; Rosenwald, A.; Trümper, L.; Leoncini, L.; Ott, G.; Siebert, R. |
| Article Title: | MicroRNA expression in high-grade B-cell lymphoma with 11q aberration |
| Abstract: | Mature aggressive B-cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B-cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) shares several biological features with both BL and DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences in miRNA expression of HGBCL-11q compared to BL and DLBCL. We evaluated the expression profiles of 2083 miRNAs in 25 HGCBL-11q, 7 BL, 131 DLBCL, and tonsils using the HTG EdgeSeq miRNA whole transcriptome assay. Uniform manifold approximation and projection (UMAP) and differential gene expression analyses based on DESeq2 were carried out. UMAP analysis of miRNA expression did not reveal distinct groups among the studied lymphomas. However, differential gene expression investigations detected sets of overexpressed miRNAs in HGBCL-11q when compared to BL (miR-9-3p, miR-9-5p, miR-3919, miR-129-1-3p, miR-129-2-3p, miR-331-3p, miR-196b-5p, and miR-28-5p) and DLBCL (miR-3919, miR-1290, miR-4538, and miR-4791), respectively. Notably, miR-3919 showed heterogeneous but significantly higher expression (p-value < 0.001) in HGBCL-11q than in both, BL and DLBCL. We identified a group of differentially expressed miRNAs between HGBCL-11q vs. BL and DLBCL, with miR-3919 as the most commonly and recurrently overexpressed miRNA in HGBCL-11q. © 2025 The Author(s). Genes, Chromosomes and Cancer published by Wiley Periodicals LLC. |
| Keywords: | controlled study; human tissue; unclassified drug; human cell; comparative study; gene overexpression; microrna; gene expression profiling; cohort analysis; down regulation; upregulation; burkitt lymphoma; diffuse large b-cell lymphoma; diffuse large b cell lymphoma; human; article; differential expression analysis; differential gene expression; whole transcriptome sequencing; aggressive b cell non hodgkin lymphoma; high-grade b-cell lymphoma with 11q aberration; micro-rnas; microrna 1258; microrna 129 1 3p; microrna 129 2 3p; microrna 1290; microrna 135b 5p; microrna 146a 5p; microrna 146b 5p; microrna 155 5p; microrna 18a 3p; microrna 1908 5p; microrna 196b 5p; microrna 208b 3p; microrna 222 5p; microrna 25 5p; microrna 28 5p; microrna 331 3p; microrna 3681 5p; microrna 3919; microrna 4314; microrna 4524a 5p; microrna 4538; microrna 4791; microrna 5010 5p; microrna 664a 3p; microrna 6805 5p; microrna 6869 5p; microrna 6889 5p; microrna 9 3p; microrna 9 5p; high grade b cell lymphoma with 11q aberration; uniform manifold approximation and projection |
| Journal Title: | Genes Chromosomes and Cancer |
| Volume: | 64 |
| Issue: | 1 |
| ISSN: | 1045-2257 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2025-01-01 |
| Start Page: | e70021 |
| Language: | English |
| DOI: | 10.1002/gcc.70021 |
| PROVIDER: | scopus |
| PMCID: | PMC11755218 |
| PUBMED: | 39846133 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
