Pediatric head and neck malignancies in the United States: A 20-year population-based study Journal Article
| Authors: | Kraguljac, S.; Hajjar, F.; Wong, R.; Shah, J.; Lopez, J. |
| Article Title: | Pediatric head and neck malignancies in the United States: A 20-year population-based study |
| Abstract: | Background: Epidemiologic data for pediatric head and neck (HN) cancers in the United States (US) have not been reported in many years. An update is essential to highlight trends to guide future treatment. Methods: We analyzed the Surveillance Epidemiology and End Results database from 2000 to 2019. We included patients aged <1–21 years with a malignancy in the HN region. We also report trends in incidence rates over time. Results: HN tumors encompassed 16.7% of all pediatric tumors with a mean age of 13.1 years. Females accounted for 59.0% of tumors. The female predominance is largely due to thyroid carcinoma; if thyroid malignancies are excluded male incidence is higher. The overall incidence (0–19 years) was found to be 3.29 malignancies per 100,000 person-years. The incidence from 2000 to 2004 was 2.84 [95% CI, 2.77, 2.91] while from 2015 to 2019 was 3.65 [3.57, 3.73]. This increase of 28.5% was greater than overall pediatric cancer, which increased by 13.7%. Incidence varies significantly by age group with 4.56 [4.35, 4.78] at age <1, 2.45 [2.37, 2.53] from 1 to 4 years, 1.46 [1.40, 1.51] from 5 to 9 years, 2.27 [2.21, 2.34] from 10 to 14 years, 4.81 [4.71, 4.90] from 15 to 19 years, and 7.35 [7.17, 7.40] from 20 to 21 years. Thus, there is a bimodal rise at the extremes of the pediatric age group. Conclusions: Pediatric HN tumors more commonly affect females. These tumors appear in a bimodal distribution; they most commonly present in very young patients and then during late adolescence The incidence has increased since 2000 and faster than overall incidence. Reporting of these data and trends will allow for advancement in treatment. © 2024 Wiley Periodicals LLC. |
| Keywords: | adolescent; adult; child; controlled study; human tissue; major clinical study; squamous cell carcinoma; united states; cancer incidence; adenocarcinoma; melanoma; childhood cancer; groups by age; hodgkin disease; tissue section; population research; infant; head and neck cancer; soft tissue sarcoma; surgery; cross-sectional study; sex difference; thyroid carcinoma; adenoid cystic carcinoma; epidemiology; trend study; acinar cell carcinoma; pediatric oncology; bone sarcoma; pediatric hematology/oncology; mucoepidermoid tumor; human; male; female; article; germ cell cancer; nerve cancer |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 72 |
| Issue: | 2 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2025-02-01 |
| Start Page: | e31452 |
| Language: | English |
| DOI: | 10.1002/pbc.31452 |
| PUBMED: | 39582100 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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