Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies Journal Article


Authors: Hammond, W. J.; Heaton, T. E.; Farber, B. A.; Mahmood, U. A.; Gluskin, J. S.; Wolden, S. L.; La Quaglia, M. P.; Sklar, C. A.; Price, A. P.
Article Title: Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies
Abstract: Purpose We performed a retrospective analysis to evaluate the risk of thyroid cancer in incidental thyroid nodules (ITNs) discovered on CT in patients with a history of pediatric cancer. Methods With IRB approval we reviewed the records of pediatric oncology patients age ≤ 21y with newly detected thyroid nodules on surveillance CT of the neck, chest, chest/abdomen/pelvis, or PET/CT performed between April 2008 and March 2015. Patients with < 6 months of follow-up after incidental findings, a history of primary thyroid malignancy, or incomplete records were excluded. Results The final cohort (N = 68) included 35 females and 33 males (mean age 16.0 ± 4.3[SD] years) with a mean follow-up time of 3.7 ± 1.9[SD] years after CT detection of ITN(s). Twenty patients (29.4%) received a follow-up thyroid ultrasound, eleven (16.2%) of whom underwent fine needle aspiration (FNA) for cytopathologic diagnosis. Among these, six (8.8%) underwent thyroid resection, with final pathology demonstrating papillary carcinoma in five (7.4%) and benign pathology in one. Conclusions Despite the low incidence of thyroid nodules and low risk of thyroid malignancy in the general pediatric population, we found a significant rate of malignancy in CT-detected ITNs in our pediatric oncology patients, and recommend ultrasound and FNA of these nodules in this high-risk population. Level of evidence Level IV, retrospective study with no comparison group. © 2017 Elsevier Inc.
Keywords: ultrasound; papillary carcinoma; thyroid nodule; children; ct; incidentaloma; adolescents
Journal Title: Journal of Pediatric Surgery
Volume: 52
Issue: 6
ISSN: 0022-3468
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2017-06-01
Start Page: 938
End Page: 943
Language: English
DOI: 10.1016/j.jpedsurg.2017.03.015
PROVIDER: scopus
PMCID: PMC5466891
PUBMED: 28347527
DOI/URL:
Notes: Article -- Export Date: 3 July 2017 -- Source: Scopus
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MSK Authors
  1. Anita P Price
    39 Price
  2. Charles A Sklar
    303 Sklar
  3. Suzanne L Wolden
    461 Wolden
  4. Todd Erin Heaton
    27 Heaton
  5. Jill Stacey Gluskin
    10 Gluskin
  6. Benjamin Asher Farber
    12 Farber
  7. Usman Ahmad Mahmood
    22 Mahmood