Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies Journal Article


Authors: Hammond, W. J.; Heaton, T. E.; Farber, B. A.; Mahmood, U. A.; Gluskin, J. S.; Wolden, S. L.; La Quaglia, M. P.; Sklar, C. A.; Price, A. P.
Article Title: Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies
Abstract: Purpose We performed a retrospective analysis to evaluate the risk of thyroid cancer in incidental thyroid nodules (ITNs) discovered on CT in patients with a history of pediatric cancer. Methods With IRB approval we reviewed the records of pediatric oncology patients age ≤ 21y with newly detected thyroid nodules on surveillance CT of the neck, chest, chest/abdomen/pelvis, or PET/CT performed between April 2008 and March 2015. Patients with < 6 months of follow-up after incidental findings, a history of primary thyroid malignancy, or incomplete records were excluded. Results The final cohort (N = 68) included 35 females and 33 males (mean age 16.0 ± 4.3[SD] years) with a mean follow-up time of 3.7 ± 1.9[SD] years after CT detection of ITN(s). Twenty patients (29.4%) received a follow-up thyroid ultrasound, eleven (16.2%) of whom underwent fine needle aspiration (FNA) for cytopathologic diagnosis. Among these, six (8.8%) underwent thyroid resection, with final pathology demonstrating papillary carcinoma in five (7.4%) and benign pathology in one. Conclusions Despite the low incidence of thyroid nodules and low risk of thyroid malignancy in the general pediatric population, we found a significant rate of malignancy in CT-detected ITNs in our pediatric oncology patients, and recommend ultrasound and FNA of these nodules in this high-risk population. Level of evidence Level IV, retrospective study with no comparison group. © 2017 Elsevier Inc.
Keywords: ultrasound; papillary carcinoma; thyroid nodule; children; ct; incidentaloma; adolescents
Journal Title: Journal of Pediatric Surgery
Volume: 52
Issue: 6
ISSN: 0022-3468
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2017-06-01
Start Page: 938
End Page: 943
Language: English
DOI: 10.1016/j.jpedsurg.2017.03.015
PROVIDER: scopus
PMCID: PMC5466891
PUBMED: 28347527
DOI/URL:
Notes: Article -- Export Date: 3 July 2017 -- Source: Scopus
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  1. Anita P Price
    53 Price
  2. Charles A Sklar
    322 Sklar
  3. Suzanne L Wolden
    560 Wolden
  4. Todd Erin Heaton
    44 Heaton
  5. Jill Stacey Gluskin
    26 Gluskin
  6. Benjamin Asher Farber
    12 Farber
  7. Usman Ahmad Mahmood
    46 Mahmood
  8. William Joseph Hammond
    13 Hammond