Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies Journal Article
| Authors: | Hammond, W. J.; Heaton, T. E.; Farber, B. A.; Mahmood, U. A.; Gluskin, J. S.; Wolden, S. L.; La Quaglia, M. P.; Sklar, C. A.; Price, A. P. |
| Article Title: | Thyroid neoplasms: Incidental findings on extent of disease evaluation CT for other pediatric malignancies |
| Abstract: | Purpose We performed a retrospective analysis to evaluate the risk of thyroid cancer in incidental thyroid nodules (ITNs) discovered on CT in patients with a history of pediatric cancer. Methods With IRB approval we reviewed the records of pediatric oncology patients age ≤ 21y with newly detected thyroid nodules on surveillance CT of the neck, chest, chest/abdomen/pelvis, or PET/CT performed between April 2008 and March 2015. Patients with < 6 months of follow-up after incidental findings, a history of primary thyroid malignancy, or incomplete records were excluded. Results The final cohort (N = 68) included 35 females and 33 males (mean age 16.0 ± 4.3[SD] years) with a mean follow-up time of 3.7 ± 1.9[SD] years after CT detection of ITN(s). Twenty patients (29.4%) received a follow-up thyroid ultrasound, eleven (16.2%) of whom underwent fine needle aspiration (FNA) for cytopathologic diagnosis. Among these, six (8.8%) underwent thyroid resection, with final pathology demonstrating papillary carcinoma in five (7.4%) and benign pathology in one. Conclusions Despite the low incidence of thyroid nodules and low risk of thyroid malignancy in the general pediatric population, we found a significant rate of malignancy in CT-detected ITNs in our pediatric oncology patients, and recommend ultrasound and FNA of these nodules in this high-risk population. Level of evidence Level IV, retrospective study with no comparison group. © 2017 Elsevier Inc. |
| Keywords: | ultrasound; papillary carcinoma; thyroid nodule; children; ct; incidentaloma; adolescents |
| Journal Title: | Journal of Pediatric Surgery |
| Volume: | 52 |
| Issue: | 6 |
| ISSN: | 0022-3468 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2017-06-01 |
| Start Page: | 938 |
| End Page: | 943 |
| Language: | English |
| DOI: | 10.1016/j.jpedsurg.2017.03.015 |
| PROVIDER: | scopus |
| PMCID: | PMC5466891 |
| PUBMED: | 28347527 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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