Chromosomal instability as a driver of cancer progression Review
| Authors: | Chen, X.; Agustinus, A. S.; Li, J.; DiBona, M.; Bakhoum, S. F. |
| Review Title: | Chromosomal instability as a driver of cancer progression |
| Abstract: | Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural and numerical chromosomal abnormalities during cell division, which contributes to tumour genetic heterogeneity. CIN has long been recognized as a hallmark of cancer, and evidence over the past decade has strongly linked CIN to tumour evolution, metastasis, immune evasion and treatment resistance. Until recently, the mechanisms by which CIN propels cancer progression have remained elusive. Beyond the generation of genomic copy number heterogeneity, recent work has unveiled additional tumour-promoting consequences of abnormal chromosome segregation. These mechanisms include complex chromosomal rearrangements, epigenetic reprogramming and the induction of cancer cell-intrinsic inflammation, emphasizing the multifaceted role of CIN in cancer. © Springer Nature Limited 2024. |
| Keywords: | genetics; review; cancer growth; neoplasm; neoplasms; animal; animals; cell division; metastasis; animal model; pathology; chromosome aberration; epigenesis, genetic; disease progression; chromosomal instability; drug therapy; genetic epigenesis; disease exacerbation; adverse drug reaction; therapy; genetic heterogeneity; chromosome segregation; etiology; immune evasion; humans; human; male; neoplastic cell transformation |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2025-01-01 |
| Start Page: | 31 |
| End Page: | 46 |
| Language: | English |
| DOI: | 10.1038/s41576-024-00761-7 |
| PUBMED: | 39075192 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK authors: Samuel F. Bakhoum -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work