cGAS–STING and the deadly CIN: How chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers Guidelines


Author: Bakhoum, S. F.
Title: cGAS–STING and the deadly CIN: How chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers
Abstract: Chromosomal instability (CIN) is a key genomic driver of human cancer. CIN generates genomic copy-number heterogeneity and tumor-derived inflammation. In a recent paper, Hong et al. identify the cGAS–STING innate immune pathway as a crucial dependency in cancer cells with CIN and pinpoint the IL6/STAT3 axis as a therapeutic vulnerability in these difficult-to-treat tumors. © 2022 Elsevier Inc.
Keywords: cancer chemotherapy; protein expression; genetics; neoplasm; neoplasms; metabolism; cell survival; stat1 protein; stat3 protein; breast cancer; inflammation; cell fate; tumor xenograft; cancer resistance; arthritis; interleukin 6; interleukin-6; short survey; chromosomal instability; upregulation; tumor gene; chronic inflammation; nucleotidyltransferase; immune evasion; nucleotidyltransferases; therapeutic index; tocilizumab; humans; human; malignant neoplasm; nf kb signaling; sting gene
Journal Title: Trends in Cancer
Volume: 8
Issue: 10
ISSN: 2405-8025
Publisher: Cell Press  
Date Published: 2022-10-01
Start Page: 788
End Page: 789
Language: English
DOI: 10.1016/j.trecan.2022.07.006
PUBMED: 35915014
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 3 October 2022 -- Source: Scopus
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  1. Samuel F Bakhoum
    81 Bakhoum