cGAS–STING and the deadly CIN: How chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers Guidelines
| Author: | Bakhoum, S. F. |
| Title: | cGAS–STING and the deadly CIN: How chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers |
| Abstract: | Chromosomal instability (CIN) is a key genomic driver of human cancer. CIN generates genomic copy-number heterogeneity and tumor-derived inflammation. In a recent paper, Hong et al. identify the cGAS–STING innate immune pathway as a crucial dependency in cancer cells with CIN and pinpoint the IL6/STAT3 axis as a therapeutic vulnerability in these difficult-to-treat tumors. © 2022 Elsevier Inc. |
| Keywords: | cancer chemotherapy; protein expression; genetics; neoplasm; neoplasms; metabolism; cell survival; stat1 protein; stat3 protein; breast cancer; inflammation; cell fate; tumor xenograft; cancer resistance; arthritis; interleukin 6; interleukin-6; short survey; chromosomal instability; upregulation; tumor gene; chronic inflammation; nucleotidyltransferase; immune evasion; nucleotidyltransferases; therapeutic index; tocilizumab; humans; human; malignant neoplasm; nf kb signaling; sting gene |
| Journal Title: | Trends in Cancer |
| Volume: | 8 |
| Issue: | 10 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2022-10-01 |
| Start Page: | 788 |
| End Page: | 789 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2022.07.006 |
| PUBMED: | 35915014 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 3 October 2022 -- Source: Scopus |
