Chromosomal instability as a source of genomic plasticity Review

   


Authors: Al-Rawi, D. H.; Bakhoum, S. F.
Review Title: Chromosomal instability as a source of genomic plasticity
Abstract: Chromosomal instability (CIN) is a hallmark of the most aggressive malignancies. Features of these tumors include complex genomic rearrangements, the presence of mis-segregated chromosomes in micronuclei, and extrachromosomal DNA (ecDNA) formation. Here, we review the development of CIN, and examine CIN in the context of cancer evolution, tumor genomic evolution, and therapeutic resistance. We also discuss the role of whole-genome duplications, breakage-fusion-bridge cycles, ecDNA or double minutes in gene amplification promoting tumor evolution. © 2022 Elsevier Ltd
Keywords: chromosomal instability; cancer evolution; micronuclei; ecdna
Journal Title: Current Opinion in Genetics and Development
Volume: 74
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2022-06-01
Start Page: 101913
Language: English
DOI: 10.1016/j.gde.2022.101913
PROVIDER: scopus
PMCID: PMC9156567
PUBMED: 35526333
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129600533&doi=10.1016%2fj.gde.2022.101913&partnerID=40&md5=a76416d67e9fcdf523c6a4e13b54cc8f
Notes: Review -- Export Date: 1 June 2022 -- Source: Scopus
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MSK Authors
  1. Samuel F Bakhoum
    81 Bakhoum
  2. Duaa Al-Rawi
    8 Al-Rawi
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