Mitotic chromosomal instability and cancer: Mouse modelling of the human disease Journal Article
| Authors: | Schvartzman, J. M.; Sotillo, R.; Benezra, R. |
| Article Title: | Mitotic chromosomal instability and cancer: Mouse modelling of the human disease |
| Abstract: | The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy is associated with increases in genomic instability. Mitotic chromosomal instability the inability to faithfully segregate equal chromosome complements to two daughter cells during mitosis is a widespread phenomenon in solid tumours that is thought to serve as the fuel for tumorigenic progression. How chromosome instability (CIN) arises in tumours and what consequences it has are still, however, hotly debated issues. Here we review the recent literature with an emphasis on models that recapitulate observations from human disease. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | leukemia; unclassified drug; gene mutation; aurora kinase inhibitor; clinical trial; review; cancer growth; liver cell carcinoma; nonhuman; solid tumor; paclitaxel; pancreas cancer; cancer staging; antineoplastic agent; neoplasms; colorectal cancer; mitosis; animals; cell viability; dna damage; gene overexpression; ovary cancer; breast cancer; gene amplification; lung non small cell cancer; lung cancer; vincristine; bladder cancer; vinblastine; hodgkin disease; carcinogenesis; chromatid; cell transformation, neoplastic; docetaxel; prostate cancer; gene expression regulation; nonhodgkin lymphoma; neuroblastoma; head and neck cancer; disease progression; colon cancer; uterine cervix cancer; stomach cancer; chromosomal instability; chromosome breakage; anaphase; models, genetic; ependymoma; thyroid carcinoma; kaposi sarcoma; rhabdomyosarcoma; navelbine; esophagus cancer; testis cancer; astrocytoma; aneuploidy; mycosis fungoides; seminoma; metaphase; nephroblastoma; 2 [[3 [4 [5 [2 (3 fluoroanilino) 2 oxoethyl] 1h pyrazol 3 ylamino] 7 quinazolinyloxy]propyl](ethyl)amino]ethyl dihydrogen phosphate; 1 cyclopropyl 3 [3 (5 morpholinomethyl 1h benzimidazol 2 yl) 1h pyrazol 4 yl]urea; 4 (8 cyclopentyl 7 ethyl 5,6,7,8 tetrahydro 5 methyl 6 oxo 2 pteridinylamino) 3 methoxy n (1 methyl 4 piperidinyl)benzamide; arry 520; azd 4877; gsk 923295; ispinesib; mk 0731; mln 8237; on 01910; p 276 00; sb 743921; chromatid aberration |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-02-01 |
| Start Page: | 102 |
| End Page: | 115 |
| Language: | English |
| DOI: | 10.1038/nrc2781 |
| PUBMED: | 20094045 |
| PROVIDER: | scopus |
| PMCID: | PMC5526619 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 20 April 2011" - "CODEN: NRCAC" - "Source: Scopus" |
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