Conserved roles of engrailed: Patterning tissues and specifying cell types Review
| Authors: | Joyner, A. L.; Ortigão-Farias, J. R.; Kornberg, T. |
| Review Title: | Conserved roles of engrailed: Patterning tissues and specifying cell types |
| Abstract: | More than 40 years ago, studies of the Drosophila engrailed and Hox genes led to major discoveries that shaped the history of developmental biology. We learned that these genes define the state of determination of cells that populate particular spatially defined regions: the identity of segmental domains by Hox genes, and the identity of posterior developmental compartments by engrailed. Hence, the boundaries that delimit spatial domains depend on engrailed. Here, we review the engrailed field, which now includes orthologs in Drosophila and mouse, as well as many other animals. We focus on fly and mouse and highlight additional functions that span early stages of embryogenesis and neural development. © 2024. Published by The Company of Biologists Ltd. |
| Keywords: | genetics; mouse; animal; metabolism; animals; mice; cerebellum; transcription factor; drosophila; embryo development; embryology; homeodomain proteins; transcription factors; gene expression regulation; gene expression regulation, developmental; homeodomain protein; drosophila proteins; body patterning; embryonic development; drosophila protein; engrailed |
| Journal Title: | Development |
| Volume: | 151 |
| Issue: | 24 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2024-12-01 |
| Start Page: | dev204250 |
| Language: | English |
| DOI: | 10.1242/dev.204250 |
| PUBMED: | 39671171 |
| PROVIDER: | scopus |
| PMCID: | PMC11664177 |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Alexandra Joyner -- Source: Scopus |
