Obesity-dependent selection of driver mutations in cancer Journal Article
| Authors: | Tang, C.; Castillon, V. J.; Waters, M.; Fong, C.; Park, T.; Boscenco, S.; Kim, S.; Pekala, K.; Carrot-Zhang, J.; Hakimi, A. A.; Schultz, N.; Ostrovnaya, I.; Gusev, A.; Jee, J.; Reznik, E. |
| Article Title: | Obesity-dependent selection of driver mutations in cancer |
| Abstract: | Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers. © The Author(s) 2024. |
| Keywords: | controlled study; middle aged; gene mutation; major clinical study; genetics; mutation; endometrium carcinoma; endometrial neoplasms; neoplasm; neoplasms; adenocarcinoma; lung neoplasms; cohort analysis; genotype; risk factors; obesity; risk factor; lung tumor; lung adenocarcinoma; genomics; cancer of unknown primary site; mutation rate; oncogene k ras; endometrium tumor; adenocarcinoma of lung; demographics; ancestry group; humans; human; male; female; article; malignant neoplasm |
| Journal Title: | Nature Genetics |
| Volume: | 56 |
| Issue: | 11 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2024-11-01 |
| Start Page: | 2318 |
| End Page: | 2321 |
| Language: | English |
| DOI: | 10.1038/s41588-024-01969-3 |
| PUBMED: | 39468367 |
| PROVIDER: | scopus |
| PMCID: | PMC11549034 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding authors are Justin Jee and Ed Reznik -- Source: Scopus |
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